TY - JOUR
T1 - Galectin-1 is essential in tumor angiogenesis and is a target for antiangiogenesis therapy
AU - Thijssen, Victor L.J.L.
AU - Postel, Ruben
AU - Brandwijk, Ricardo J.M.G.E.
AU - Dings, Ruud P.M.
AU - Nesmelova, Irina
AU - Satijn, Sietske
AU - Verhofstad, Nicole
AU - Nakabeppu, Yusaku
AU - Baum, Linda G.
AU - Bakkers, Jeroen
AU - Mayo, Kevin H.
AU - Poirier, Françoise
AU - Griffioen, Arjan W.
PY - 2006/10/24
Y1 - 2006/10/24
N2 - We describe that galectin-1 (gal-1) is a receptor for the angiogenesis inhibitor anginex, and that the protein is crucial for tumor angiogenesis. gal-1 is overexpressed in endothelial cells of different human tumors. Expression knockdown in cultured endothelial cells inhibits cell proliferation and migration. The importance of gal-1 in angiogenesis is illustrated in the zebrafish model, where expression knockdown results in impaired vascular guidance and growth of dysfunctional vessels. The role of gal-1 in tumor angiogenesis is demonstrated in gal-1-null mice, in which tumor growth is markedly impaired because of insufficient tumor angiogenesis. Furthermore, tumor growth in gal-1-null mice no longer responds to antiangiogenesis treatment by anginex. Thus, gal-1 regulates tumor angiogenesis and is a target for angiostatic cancer therapy.
AB - We describe that galectin-1 (gal-1) is a receptor for the angiogenesis inhibitor anginex, and that the protein is crucial for tumor angiogenesis. gal-1 is overexpressed in endothelial cells of different human tumors. Expression knockdown in cultured endothelial cells inhibits cell proliferation and migration. The importance of gal-1 in angiogenesis is illustrated in the zebrafish model, where expression knockdown results in impaired vascular guidance and growth of dysfunctional vessels. The role of gal-1 in tumor angiogenesis is demonstrated in gal-1-null mice, in which tumor growth is markedly impaired because of insufficient tumor angiogenesis. Furthermore, tumor growth in gal-1-null mice no longer responds to antiangiogenesis treatment by anginex. Thus, gal-1 regulates tumor angiogenesis and is a target for angiostatic cancer therapy.
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U2 - 10.1073/pnas.0603883103
DO - 10.1073/pnas.0603883103
M3 - Article
C2 - 17043243
AN - SCOPUS:33750474852
SN - 0027-8424
VL - 103
SP - 15975
EP - 15980
JO - Proceedings of the National Academy of Sciences of the United States of America
JF - Proceedings of the National Academy of Sciences of the United States of America
IS - 43
ER -
