12 and Gα13 as key regulatory mediator in signal transduction

Hitoshi Kurose

Research output: Contribution to journalArticlepeer-review

92 Citations (Scopus)


It is generally thought that Gα12 and Gα 13-induced responses are exclusively mediated by small G protein Rho. However, Gα12 and Gα13 elicit divergent cellular responses: phospholipase C-ε activation, phospholipase D activation, cytoskeletal change, oncogenic response, apoptosis, MAP kinase activation and Na/H-exchange activation. In addition to Rho activation through RhoGEF, it has been recently demonstrated that Gα12 and Gα13 interact with several proteins and regulate their activities. However, physiological importance of the interaction of Gα12 and Gα13 with these proteins has not fully established. I summarize the recent progress of Gα12 and Gα13-mediated signaling cascade.

Original languageEnglish
Pages (from-to)155-161
Number of pages7
JournalLife Sciences
Issue number2-3
Publication statusPublished - Dec 5 2003
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • General Pharmacology, Toxicology and Pharmaceutics
  • General Biochemistry,Genetics and Molecular Biology


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