TY - JOUR
T1 - Functional segregation and development of mouse higher visual areas
AU - Murakami, Tomonari
AU - Matsui, Teppei
AU - Ohki, Kenichi
N1 - Funding Information:
ThisworkwassupportedbyBrainMappingbyIntegratedNeurotechnologiesforDiseaseStudies(Brain/MINDS), JapanAgencyforMedicalResearchandDevelopment(AMED);CoreResearchforEvolutionaryScienceandTechnol-ogy (CREST), AMED; Strategic International Research Cooperative Program (SICP), AMED; and the Japan Society for the Promotion of Sciences (JSPS) (KAKENHI Grants 25221001 and 25117004 to K.O. and Research Fellowships 201204982 and 15H06473 to T. Matsui and 20153597 to T. Murakami). We thank T. Yoshida for building the experimentalsetupforeyetracking,A.HondaandY.Sonoforanimalcareandgenotyping,andtheResearchSupport Center, Graduate School of Medical Sciences, Kyushu, for technical support. The authors declare no competing financial interests.
Publisher Copyright:
© 2017 the authors.
PY - 2017/9/27
Y1 - 2017/9/27
N2 - Recent studies suggest that higher visual areas (HVAs) in the mouse visual cortex are segregated anatomically into two visual streams, likely analogous to the ventral and dorsal streams in primates. However, HVAs in mice have yet to be characterized functionally. Moreover, it is unknown when the functional segregation of HVAs occurs during development. Here, we investigated spatiotemporal selectivity of HVAs and their development using wide-field calcium imaging. We found that lateral HVAs in the anatomical ventral stream shared similar spatiotemporal selectivity, whereas the spatiotemporal selectivity of anterior and medial HVAs in the anatomical dorsal stream was not uniform and these areas were segregated functionally into multiple groups. This functional segregation of HVAs developed and reached an adult-like pattern ~ 10 d after eye opening (EO). These results suggest, not only the functional segregation of ventral and dorsal streams, but also the presence of multiple substreams in the dorsal stream, and indicate that the functional segregation of visual streams occurs gradually after EO.
AB - Recent studies suggest that higher visual areas (HVAs) in the mouse visual cortex are segregated anatomically into two visual streams, likely analogous to the ventral and dorsal streams in primates. However, HVAs in mice have yet to be characterized functionally. Moreover, it is unknown when the functional segregation of HVAs occurs during development. Here, we investigated spatiotemporal selectivity of HVAs and their development using wide-field calcium imaging. We found that lateral HVAs in the anatomical ventral stream shared similar spatiotemporal selectivity, whereas the spatiotemporal selectivity of anterior and medial HVAs in the anatomical dorsal stream was not uniform and these areas were segregated functionally into multiple groups. This functional segregation of HVAs developed and reached an adult-like pattern ~ 10 d after eye opening (EO). These results suggest, not only the functional segregation of ventral and dorsal streams, but also the presence of multiple substreams in the dorsal stream, and indicate that the functional segregation of visual streams occurs gradually after EO.
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U2 - 10.1523/JNEUROSCI.0731-17.2017
DO - 10.1523/JNEUROSCI.0731-17.2017
M3 - Article
C2 - 28847805
AN - SCOPUS:85030179121
SN - 0270-6474
VL - 37
SP - 9424
EP - 9437
JO - Journal of Neuroscience
JF - Journal of Neuroscience
IS - 39
ER -