Functional prognosis of critical limb ischemia and efficacy of restoration of direct flow below the ankle

Tadashi Furuyama, Toshihiro Onohara, Ryosuke Yoshiga, Keiji Yoshiya, Yutaka Matsubara, Kentaro Inoue, Daisuke Matsuda, Koichi Morisaki, Takuya Matsumoto, Yoshihiko Maehara

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)


Objective: Patients with critical limb ischemia have serious systemic comorbidities and are at high risk of impairment of limb function. In this study, we assessed the prognostic factors of limbs after revascularization. Methods: In this retrospective single-center cohort study, from April 2008 to December 2012, we treated 154 limbs of 121 patients with critical limb ischemia by the endovascular therapy-first approach based on the patients’ characteristics. The primary end point was amputation-free survival. Secondary end points were patency of a revascularized artery, major adverse limb events, or death. Furthermore, we investigated the ambulatory status one year after revascularization as prognosis of limb function. Results: Endovascular therapy was performed in 85 limbs in 65 patients as the initial therapy (endovascular therapy group) and surgical reconstructive procedures (bypass group) were performed in 69 limbs in 56 patients. Early mortality within 30 days was not observed in either group. The primary patency rate was significantly better in the bypass group than in the endovascular therapy group (p < 0.0001). Furthermore, the secondary patency rate was similar between the two groups (p = 0.0096). There were no significant differences in amputation-free survival and major adverse limb event between the two groups. Univariate analysis showed that ulcer healing (p < 0.0001), no hypoalbuminemia (p = 0.0019), restoration of direct flow below the ankle (p = 0.0219), no previous cerebrovascular disease (p = 0.0389), and Rutherford 4 (p = 0.0469) were predictive factors for preservation of ambulatory status one year after revascularization. In multivariate analysis, ulcer healing (p < 0.0001) and restoration of direct flow below the ankle (p = 0.0060) were significant predictors. Conclusions: Ulcer healing and restoration of direct flow below the ankle are independently associated with prognosis of limb functions in patients who undergo infrainguinal arterial reconstruction.

Original languageEnglish
Pages (from-to)38-45
Number of pages8
Issue number1
Publication statusPublished - Feb 1 2019

All Science Journal Classification (ASJC) codes

  • Surgery
  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine


Dive into the research topics of 'Functional prognosis of critical limb ischemia and efficacy of restoration of direct flow below the ankle'. Together they form a unique fingerprint.

Cite this