Functional MRI study of brain activation alterations in patients with obsessive-compulsive disorder after symptom improvement

Maiko Nabeyama, Akiko Nakagawa, Takashi Yoshiura, Tomohiro Nakao, Eriko Nakatani, Osamu Togao, Chika Yoshizato, Kazuko Yoshioka, Mayumi Tomita, Shigenobu Kanba

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114 Citations (Scopus)


Dysfunction of the frontal-subcortical circuits has been the most common finding in the pathophysiology of obsessive-compulsive disorder (OCD), and recent neuropsychological studies have shown cognitive impairments in OCD. To clarify the pathophysiology of OCD without the confounding effects of medication, we investigated the alterations of brain function in OCD patients and changes after clinical improvement due solely to behavior therapy. The participants were 11 outpatients with OCD and 19 normal controls. The patients received 12 weeks of behavior therapy. We investigated the differences in the behavioral performance and functional magnetic resonance imaging results during the Stroop test in the patients and normal controls, and their changes after treatment in the patients. The patients showed less activation in the anterior cingulate gyrus and cerebellum than control subjects. Following significant improvement in OC symptoms, the cerebellum and parietal lobe showed increased activation, and the orbitofrontal cortex, middle frontal gyrus, and temporal regions showed decreased activation during the Stroop task, and performance of the task itself improved. Our findings suggest that dysfunction of the posterior brain regions, especially the cerebellum, is involved in the pathogenesis of OCD, and that normalization in function can occur with improvement of OC symptoms.

Original languageEnglish
Pages (from-to)236-247
Number of pages12
JournalPsychiatry Research - Neuroimaging
Issue number3
Publication statusPublished - Aug 30 2008

All Science Journal Classification (ASJC) codes

  • Neuroscience (miscellaneous)
  • Radiology Nuclear Medicine and imaging
  • Psychiatry and Mental health


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