From organoids to transplantable artificial kidneys

Hidekazu Naganuma; Ryuichi Nishinakamura

doi:10.1111/tri.13404

From organoids to transplantable artificial kidneys

Hidekazu Naganuma, Ryuichi Nishinakamura

Research output: Contribution to journal › Review article › peer-review

10 Citations (Scopus)

Abstract

It is difficult to restore kidney function following chronic kidney damage. Although dialysis is currently used to treat patients with chronic kidney disease, it does not cure the disease, while severely restricting the patient's daily and social activities. Kidney transplantation is an alternative and curative therapy, but donor numbers remain limited. However, the generation of kidney organoids from human induced pluripotent stem cells represents an important recent advance in regenerative medicine. Kidney organoids are expected to be used for disease modeling and drug discovery, and may eventually be applicable for transplantation. In this review, we describe the current status of kidney organoids and discuss the hurdles that need to be overcome to generate transplantable artificial kidneys.

Original language	English
Pages (from-to)	563-570
Number of pages	8
Journal	Transplant International
Volume	32
Issue number	6
DOIs	https://doi.org/10.1111/tri.13404
Publication status	Published - Jun 2019
Externally published	Yes

All Science Journal Classification (ASJC) codes

Transplantation

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1111/tri.13404

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abstract = "It is difficult to restore kidney function following chronic kidney damage. Although dialysis is currently used to treat patients with chronic kidney disease, it does not cure the disease, while severely restricting the patient's daily and social activities. Kidney transplantation is an alternative and curative therapy, but donor numbers remain limited. However, the generation of kidney organoids from human induced pluripotent stem cells represents an important recent advance in regenerative medicine. Kidney organoids are expected to be used for disease modeling and drug discovery, and may eventually be applicable for transplantation. In this review, we describe the current status of kidney organoids and discuss the hurdles that need to be overcome to generate transplantable artificial kidneys.",

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AB - It is difficult to restore kidney function following chronic kidney damage. Although dialysis is currently used to treat patients with chronic kidney disease, it does not cure the disease, while severely restricting the patient's daily and social activities. Kidney transplantation is an alternative and curative therapy, but donor numbers remain limited. However, the generation of kidney organoids from human induced pluripotent stem cells represents an important recent advance in regenerative medicine. Kidney organoids are expected to be used for disease modeling and drug discovery, and may eventually be applicable for transplantation. In this review, we describe the current status of kidney organoids and discuss the hurdles that need to be overcome to generate transplantable artificial kidneys.

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From organoids to transplantable artificial kidneys

Abstract

All Science Journal Classification (ASJC) codes

UN SDGs

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