Fresh frozen plasma transfusion does not affect outcomes following hepatic resection for hepatocellular carcinoma

Yoshito Tomimaru, Hiroshi Wada, Shigeru Marubashi, Shogo Kobayashi, Hidetoshi Eguchi, Yutaka Takeda, Masahiro Tanemura, Takehiro Noda, Koji Umeshita, Yuichiro Doki, Masaki Mori, Hiroaki Nagano

Research output: Contribution to journalArticlepeer-review

25 Citations (Scopus)


AIM: To investigate whether fresh frozen plasma (FFP) transfusion affects outcomes following hepatic resection for hepatocellular carcinoma (HCC) in terms of liver function, postoperative complications and cancer prognosis. METHODS: We retrospectively compared the incidence of postoperative complications between 204 patients who underwent hepatectomy for HCC with routine FFP transfusion in an early period (1983-1993, Group A) and 293 with necessity for FFP transfusion during a later period (1998-2006, Group B), and also between two subgroups of Group B [22 patients with FFP transfusion (Group B1) and 275 patients without FFP transfusion (Group B2)]. Additionally, only in limited patients in Group B1 and Group B2 with intraoperative blood loss ≥ 2000 mL (Group B1≥ 2000 mL and Group B2≥ 2000 mL), postoperative complications, liver function tests, and cancer prognosis were compared. RESULTS: No mortality was registered in Group B, compared to 8 patients (3.9%) of Group A. The incidence of morbidity in Group B2 [23.2% (64/275)] was not significantly different from Group B1 [40.9% (9/22)] and Group A [27.0% (55/204)]. The incidence of complications and postoperative liver function tests were comparable between Group B1≥ 2000 mL vs Group B2≥ 2000 mL. Postoperative prognosis did not correlate with administration of FFP, but with tumor-related factors. CONCLUSION: The outcome of hepatectomy for HCC is not influenced by FFP transfusion. We suggest FFP transfusion be abandoned in patients who undergo hepatectomy for HCC.

Original languageEnglish
Pages (from-to)5603-5610
Number of pages8
JournalWorld Journal of Gastroenterology
Issue number44
Publication statusPublished - Nov 28 2010
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Gastroenterology


Dive into the research topics of 'Fresh frozen plasma transfusion does not affect outcomes following hepatic resection for hepatocellular carcinoma'. Together they form a unique fingerprint.

Cite this