Four new cembrane diterpenes isolated from an Okinawan soft coral Lobophytum crassum with inhibitory effects on nitric oxide production

Mpanzu Wanzola; Takaaki Furuta; Yasuhisa Kohno; Shunichi Fukumitsu; Shuhei Yasukochi; Kosuke Watari; Chiaki Tanaka; Ryuichi Higuchi; Tomofumi Miyamoto

doi:10.1248/cpb.58.1203

Four new cembrane diterpenes isolated from an Okinawan soft coral Lobophytum crassum with inhibitory effects on nitric oxide production

Mpanzu Wanzola, Takaaki Furuta, Yasuhisa Kohno, Shunichi Fukumitsu, Shuhei Yasukochi, Kosuke Watari, Chiaki Tanaka, Ryuichi Higuchi, Tomofumi Miyamoto

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30 Citations (Scopus)

Abstract

Four new cembrane diterpenes (1-4) and fifteen known cembranoids (5-19) were isolated from an Okinawan soft coral Lobophytum crassum. The structures of these four new cembranoids were determined on the basis of spectroscopic evidence. In particular, the absolute stereochemistry of 1, 2, 5 and 6 were elucidated by the application of the modified Mosher's method and circular dichroism (CD) spectral data. The inhibitory effects of some isolates were evaluated on nitric oxide (NO) production against a murine macrophage-like cell line (Raw 264.7). Cembranoids consisting of α-methylene-γ-lactone, exhibited the significant effect on NO production.

Original language	English
Pages (from-to)	1203-1209
Number of pages	7
Journal	Chemical and Pharmaceutical Bulletin
Volume	58
Issue number	9
DOIs	https://doi.org/10.1248/cpb.58.1203
Publication status	Published - Sept 2010

All Science Journal Classification (ASJC) codes

Chemistry(all)
Drug Discovery

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title = "Four new cembrane diterpenes isolated from an Okinawan soft coral Lobophytum crassum with inhibitory effects on nitric oxide production",

abstract = "Four new cembrane diterpenes (1-4) and fifteen known cembranoids (5-19) were isolated from an Okinawan soft coral Lobophytum crassum. The structures of these four new cembranoids were determined on the basis of spectroscopic evidence. In particular, the absolute stereochemistry of 1, 2, 5 and 6 were elucidated by the application of the modified Mosher's method and circular dichroism (CD) spectral data. The inhibitory effects of some isolates were evaluated on nitric oxide (NO) production against a murine macrophage-like cell line (Raw 264.7). Cembranoids consisting of α-methylene-γ-lactone, exhibited the significant effect on NO production.",

author = "Mpanzu Wanzola and Takaaki Furuta and Yasuhisa Kohno and Shunichi Fukumitsu and Shuhei Yasukochi and Kosuke Watari and Chiaki Tanaka and Ryuichi Higuchi and Tomofumi Miyamoto",

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AU - Wanzola, Mpanzu

AU - Furuta, Takaaki

AU - Kohno, Yasuhisa

AU - Fukumitsu, Shunichi

AU - Yasukochi, Shuhei

AU - Watari, Kosuke

AU - Tanaka, Chiaki

AU - Higuchi, Ryuichi

AU - Miyamoto, Tomofumi

PY - 2010/9

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AB - Four new cembrane diterpenes (1-4) and fifteen known cembranoids (5-19) were isolated from an Okinawan soft coral Lobophytum crassum. The structures of these four new cembranoids were determined on the basis of spectroscopic evidence. In particular, the absolute stereochemistry of 1, 2, 5 and 6 were elucidated by the application of the modified Mosher's method and circular dichroism (CD) spectral data. The inhibitory effects of some isolates were evaluated on nitric oxide (NO) production against a murine macrophage-like cell line (Raw 264.7). Cembranoids consisting of α-methylene-γ-lactone, exhibited the significant effect on NO production.

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Four new cembrane diterpenes isolated from an Okinawan soft coral Lobophytum crassum with inhibitory effects on nitric oxide production

Abstract

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