Forsskamide, a new ceramide from aerial parts of Forsskaolea tenacissima Linn.

Hamdy K. Assaf; Alaa M. Nafady; Ahmed E. Allam; Ashraf N.E. Hamed; Mohamed S. Kamel; Kuniyoshi Shimizu

doi:10.1080/14786419.2017.1419234

Forsskamide, a new ceramide from aerial parts of Forsskaolea tenacissima Linn.

Hamdy K. Assaf, Alaa M. Nafady, Ahmed E. Allam, Ashraf N.E. Hamed, Mohamed S. Kamel, Kuniyoshi Shimizu

Sustainable Bioresources Science

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

Although the various folk medicine uses and the biological activity of Forsskaolea tenacissima L., few chemical constituents of this plant have been reported, this provoked us to make our study. Forsskamide, a new ceramide was isolated from aerial parts of F. tenacissima L. (Urticaceae). The chemical structure was established by different spectroscopic methods (¹H, ¹³C-NMR, HMBC, HSQC, ROESY, FAB-MS and HR-FAB-MS). Forsskamide showed a moderate cytotoxic activity by (MTT) method against human colorectal carcinoma cell line (HCT-116) with IC₅₀ 33.25 μM in comparison with 5-fluorouracil IC₅₀ 26.42 μM. While, it did not show any activity against human hepatocarcinaoma cell line (HepG-2).

Original language	English
Pages (from-to)	2452-2456
Number of pages	5
Journal	Natural Product Research
Volume	32
Issue number	20
DOIs	https://doi.org/10.1080/14786419.2017.1419234
Publication status	Published - Oct 18 2018

All Science Journal Classification (ASJC) codes

Analytical Chemistry
Biochemistry
Plant Science
Organic Chemistry

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10.1080/14786419.2017.1419234

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title = "Forsskamide, a new ceramide from aerial parts of Forsskaolea tenacissima Linn.",

abstract = "Although the various folk medicine uses and the biological activity of Forsskaolea tenacissima L., few chemical constituents of this plant have been reported, this provoked us to make our study. Forsskamide, a new ceramide was isolated from aerial parts of F. tenacissima L. (Urticaceae). The chemical structure was established by different spectroscopic methods (1H, 13C-NMR, HMBC, HSQC, ROESY, FAB-MS and HR-FAB-MS). Forsskamide showed a moderate cytotoxic activity by (MTT) method against human colorectal carcinoma cell line (HCT-116) with IC50 33.25 μM in comparison with 5-fluorouracil IC50 26.42 μM. While, it did not show any activity against human hepatocarcinaoma cell line (HepG-2).",

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AU - Assaf, Hamdy K.

AU - Nafady, Alaa M.

AU - Allam, Ahmed E.

AU - Hamed, Ashraf N.E.

AU - Kamel, Mohamed S.

AU - Shimizu, Kuniyoshi

PY - 2018/10/18

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Forsskamide, a new ceramide from aerial parts of Forsskaolea tenacissima Linn.

Abstract

All Science Journal Classification (ASJC) codes

UN SDGs

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