TY - JOUR
T1 - Formation of drusen in the human eye
AU - Ishibashi, Tatsuro
AU - Patterson, Randi
AU - Ohnishi, Yoshitaka
AU - Inomata, Hajime
AU - Ryan, Stephen J.
N1 - Funding Information:
Accepted for publication Jan. 9, 1986. From the Department of Ophthalmology, University of Southern California School of Medicine and the Estelle Doheny Eye Foundation, Los Angeles, California (Dr. Ishibashi, Ms. Patterson, and Dr. Ryan) and the Department of Ophthalmology, Faculty of Medicine, Kyushu University, Fukuoka, Japan (Drs. Ohnishi and Inomata). This study was supported in part by grant No. EY01545 from the National Institutes of Health (Dr. Ryan). Reprint requests to Stephen J. Ryan, M.D., U.S.c. Department of Ophthalmology, Estelle Doheny Eye Foundation, 1355 San Pablo St., Los Angeles, CA 90033.
PY - 1986/3/15
Y1 - 1986/3/15
N2 - Light and electron microscopy of drusen formation in the human eye showed yellow-white spots in the fundus with two morphologic patterns: that of typical drusen and a nodular accumulation of cellular components beneath the retinal pigment epithelial cells. By electron microscopy, the progression of drusen formation could be classified into four stages. Stage I showed budding or evagination of retinal pigment epithelial cells into the subpigment epithelial space. This evaginated portion was connected to the retinal pigment epithelial cell cytoplasm and was surrounded by its basement membrane. In Stage II the evaginated portion of the cell was completely separate from the cytoplasm of its parent retinal pigment epithelial cell. In Stage III, the evaginated portion showed degeneration and disintegration. Finally, in Stage IV, an accumulation of vesicular, granular, tubular, and linear material was seen free within the nodular space beneath the retinal pigment epithelial cell.
AB - Light and electron microscopy of drusen formation in the human eye showed yellow-white spots in the fundus with two morphologic patterns: that of typical drusen and a nodular accumulation of cellular components beneath the retinal pigment epithelial cells. By electron microscopy, the progression of drusen formation could be classified into four stages. Stage I showed budding or evagination of retinal pigment epithelial cells into the subpigment epithelial space. This evaginated portion was connected to the retinal pigment epithelial cell cytoplasm and was surrounded by its basement membrane. In Stage II the evaginated portion of the cell was completely separate from the cytoplasm of its parent retinal pigment epithelial cell. In Stage III, the evaginated portion showed degeneration and disintegration. Finally, in Stage IV, an accumulation of vesicular, granular, tubular, and linear material was seen free within the nodular space beneath the retinal pigment epithelial cell.
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U2 - 10.1016/0002-9394(86)90830-5
DO - 10.1016/0002-9394(86)90830-5
M3 - Article
C2 - 3953728
AN - SCOPUS:0022578257
SN - 0002-9394
VL - 101
SP - 342
EP - 353
JO - American journal of ophthalmology
JF - American journal of ophthalmology
IS - 3
ER -