Five-Year Changes in Cognitive Function and Their Predictor in Adult Moyamoya Disease

Akira Nakamizo; Toshiyuki Amano; Satoshi Matsuo; Yuichiro Miyamatsu; Takahiro Kuwashiro; Masahiro Yasaka; Yasushi Okada; Masahiro Mizoguchi; Koji Yoshimoto

doi:10.1016/j.wneu.2022.06.055

Five-Year Changes in Cognitive Function and Their Predictor in Adult Moyamoya Disease

Akira Nakamizo, Toshiyuki Amano, Satoshi Matsuo, Yuichiro Miyamatsu, Takahiro Kuwashiro, Masahiro Yasaka, Yasushi Okada, Masahiro Mizoguchi, Koji Yoshimoto

Department of Neurosurgery

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

Objective: The long-term outcomes of cognitive function in moyamoya disease remain unknown. We aimed to assess 5-year changes in cognitive function in adult moyamoya disease patients and to evaluate the value of the magnetic resonance angiography (MRA) steno-occlusive score to predict cognitive changes. Methods: Participants comprised 20 consecutive patients whose cognitive functions had been evaluated using the Frontal Assessment Battery (FAB) and Neurobehavioral Cognitive Status Examination (Cognistat) at baseline and reassessed 5 years later. Results: The total FAB score and total Cognistat score were lower after 5 years in 9 patients each. The Wilcoxon signed-rank test showed that subscores for conceptualization and comprehension increased, while subscores for mental flexibility, programming, and inhibitory control significantly decreased after 5 years. The right MRA total score and right posterior cerebral artery score were negatively associated with 5-year changes in the total FAB score and total Cognistat score. The right posterior cerebral artery score was significantly associated with changes in subscores for mental flexibility, programming, sensitivity to interference, and construction. Conclusions: Specific cognitive domains can decline over time in patients with adult moyamoya disease. MRA findings might be useful for predicting future declines in cognitive function.

Original language	English
Journal	World Neurosurgery
DOIs	https://doi.org/10.1016/j.wneu.2022.06.055
Publication status	Accepted/In press - 2022

All Science Journal Classification (ASJC) codes

Surgery
Clinical Neurology

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10.1016/j.wneu.2022.06.055

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@article{b35041bfb07e41dd92cf866d99a5c23d,

title = "Five-Year Changes in Cognitive Function and Their Predictor in Adult Moyamoya Disease",

abstract = "Objective: The long-term outcomes of cognitive function in moyamoya disease remain unknown. We aimed to assess 5-year changes in cognitive function in adult moyamoya disease patients and to evaluate the value of the magnetic resonance angiography (MRA) steno-occlusive score to predict cognitive changes. Methods: Participants comprised 20 consecutive patients whose cognitive functions had been evaluated using the Frontal Assessment Battery (FAB) and Neurobehavioral Cognitive Status Examination (Cognistat) at baseline and reassessed 5 years later. Results: The total FAB score and total Cognistat score were lower after 5 years in 9 patients each. The Wilcoxon signed-rank test showed that subscores for conceptualization and comprehension increased, while subscores for mental flexibility, programming, and inhibitory control significantly decreased after 5 years. The right MRA total score and right posterior cerebral artery score were negatively associated with 5-year changes in the total FAB score and total Cognistat score. The right posterior cerebral artery score was significantly associated with changes in subscores for mental flexibility, programming, sensitivity to interference, and construction. Conclusions: Specific cognitive domains can decline over time in patients with adult moyamoya disease. MRA findings might be useful for predicting future declines in cognitive function.",

author = "Akira Nakamizo and Toshiyuki Amano and Satoshi Matsuo and Yuichiro Miyamatsu and Takahiro Kuwashiro and Masahiro Yasaka and Yasushi Okada and Masahiro Mizoguchi and Koji Yoshimoto",

note = "Funding Information: Conflict of interest statement: The authors declare that the article content was composed in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. Publisher Copyright: {\textcopyright} 2022 Elsevier Inc.",

year = "2022",

doi = "10.1016/j.wneu.2022.06.055",

language = "English",

journal = "World Neurosurgery",

issn = "1878-8750",

publisher = "Elsevier Inc.",

}

TY - JOUR

T1 - Five-Year Changes in Cognitive Function and Their Predictor in Adult Moyamoya Disease

AU - Nakamizo, Akira

AU - Amano, Toshiyuki

AU - Matsuo, Satoshi

AU - Miyamatsu, Yuichiro

AU - Kuwashiro, Takahiro

AU - Yasaka, Masahiro

AU - Okada, Yasushi

AU - Mizoguchi, Masahiro

AU - Yoshimoto, Koji

N1 - Funding Information: Conflict of interest statement: The authors declare that the article content was composed in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. Publisher Copyright: © 2022 Elsevier Inc.

PY - 2022

Y1 - 2022

N2 - Objective: The long-term outcomes of cognitive function in moyamoya disease remain unknown. We aimed to assess 5-year changes in cognitive function in adult moyamoya disease patients and to evaluate the value of the magnetic resonance angiography (MRA) steno-occlusive score to predict cognitive changes. Methods: Participants comprised 20 consecutive patients whose cognitive functions had been evaluated using the Frontal Assessment Battery (FAB) and Neurobehavioral Cognitive Status Examination (Cognistat) at baseline and reassessed 5 years later. Results: The total FAB score and total Cognistat score were lower after 5 years in 9 patients each. The Wilcoxon signed-rank test showed that subscores for conceptualization and comprehension increased, while subscores for mental flexibility, programming, and inhibitory control significantly decreased after 5 years. The right MRA total score and right posterior cerebral artery score were negatively associated with 5-year changes in the total FAB score and total Cognistat score. The right posterior cerebral artery score was significantly associated with changes in subscores for mental flexibility, programming, sensitivity to interference, and construction. Conclusions: Specific cognitive domains can decline over time in patients with adult moyamoya disease. MRA findings might be useful for predicting future declines in cognitive function.

AB - Objective: The long-term outcomes of cognitive function in moyamoya disease remain unknown. We aimed to assess 5-year changes in cognitive function in adult moyamoya disease patients and to evaluate the value of the magnetic resonance angiography (MRA) steno-occlusive score to predict cognitive changes. Methods: Participants comprised 20 consecutive patients whose cognitive functions had been evaluated using the Frontal Assessment Battery (FAB) and Neurobehavioral Cognitive Status Examination (Cognistat) at baseline and reassessed 5 years later. Results: The total FAB score and total Cognistat score were lower after 5 years in 9 patients each. The Wilcoxon signed-rank test showed that subscores for conceptualization and comprehension increased, while subscores for mental flexibility, programming, and inhibitory control significantly decreased after 5 years. The right MRA total score and right posterior cerebral artery score were negatively associated with 5-year changes in the total FAB score and total Cognistat score. The right posterior cerebral artery score was significantly associated with changes in subscores for mental flexibility, programming, sensitivity to interference, and construction. Conclusions: Specific cognitive domains can decline over time in patients with adult moyamoya disease. MRA findings might be useful for predicting future declines in cognitive function.

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ER -

Five-Year Changes in Cognitive Function and Their Predictor in Adult Moyamoya Disease

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