First total synthesis of prunustatin A

Shuhei Yamakoshi, Eiji Kawanishi

Research output: Contribution to journalArticlepeer-review

15 Citations (Scopus)


In this study, we achieved the first total synthesis of natural prunustatin A (1), a novel inhibitor of glucose-regulated protein 78 (GRP78) expression. A key feature included a 15-membered ring macrocyclization, which was successfully accomplished by employing Shiina macrolactonization using 2-methyl-6- nitrobenzoic anhydride (MNBA) and 4-dimethylaminopyridine (DMAP).

Original languageEnglish
Pages (from-to)1175-1177
Number of pages3
JournalTetrahedron Letters
Issue number6
Publication statusPublished - Feb 5 2014
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry


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