First total synthesis of dl-duocarmycin A

Yasumichi Fukuda; Kazuhiko Nakatani; Yoshio Ito; Shiro Terashima

doi:10.1016/S0040-4039(00)97151-X

First total synthesis of dl-duocarmycin A

Yasumichi Fukuda, Kazuhiko Nakatani, Yoshio Ito, Shiro Terashima

Research output: Contribution to journal › Article › peer-review

37 Citations (Scopus)

Abstract

The title synthesis could be achieved by featuring introduction of a methoxycarbonyl group into the C-4 position of a 5-aminoindoline nucleus by way of an isatin derivative and subsequent ring closure to a methyl 2-methylindoxyl-2-carboxylate system by the Dieckmann cyclization.

Original language	English
Pages (from-to)	6699-6702
Number of pages	4
Journal	Tetrahedron Letters
Volume	31
Issue number	46
DOIs	https://doi.org/10.1016/S0040-4039(00)97151-X
Publication status	Published - Jan 1 1990
Externally published	Yes

All Science Journal Classification (ASJC) codes

Biochemistry
Drug Discovery
Organic Chemistry

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10.1016/S0040-4039(00)97151-X

Cite this

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title = "First total synthesis of dl-duocarmycin A",

abstract = "The title synthesis could be achieved by featuring introduction of a methoxycarbonyl group into the C-4 position of a 5-aminoindoline nucleus by way of an isatin derivative and subsequent ring closure to a methyl 2-methylindoxyl-2-carboxylate system by the Dieckmann cyclization.",

author = "Yasumichi Fukuda and Kazuhiko Nakatani and Yoshio Ito and Shiro Terashima",

year = "1990",

month = jan,

day = "1",

doi = "10.1016/S0040-4039(00)97151-X",

language = "English",

volume = "31",

pages = "6699--6702",

journal = "Tetrahedron Letters",

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TY - JOUR

T1 - First total synthesis of dl-duocarmycin A

AU - Fukuda, Yasumichi

AU - Nakatani, Kazuhiko

AU - Ito, Yoshio

AU - Terashima, Shiro

PY - 1990/1/1

Y1 - 1990/1/1

N2 - The title synthesis could be achieved by featuring introduction of a methoxycarbonyl group into the C-4 position of a 5-aminoindoline nucleus by way of an isatin derivative and subsequent ring closure to a methyl 2-methylindoxyl-2-carboxylate system by the Dieckmann cyclization.

AB - The title synthesis could be achieved by featuring introduction of a methoxycarbonyl group into the C-4 position of a 5-aminoindoline nucleus by way of an isatin derivative and subsequent ring closure to a methyl 2-methylindoxyl-2-carboxylate system by the Dieckmann cyclization.

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U2 - 10.1016/S0040-4039(00)97151-X

DO - 10.1016/S0040-4039(00)97151-X

M3 - Article

AN - SCOPUS:0025026518

SN - 0040-4039

VL - 31

SP - 6699

EP - 6702

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 46

ER -

First total synthesis of dl-duocarmycin A

Abstract

All Science Journal Classification (ASJC) codes

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