First enantioselective total synthesis of (-)-heliannuol C

Tomoyo Kamei, Mitsuru Shindo, Kozo Shishido

Research output: Contribution to journalArticlepeer-review

51 Citations (Scopus)


The first, efficient total synthesis of (-)-heliannuol C (1) was accomplished enantioselectively, using a chemoenzymatic desymmetrization of the σ-symmetrical diol, a ring closing metathesis, a diastereoselective epoxidation, and a regioselective reductive cleavage of epoxide as the key reaction steps.

Original languageEnglish
Pages (from-to)8505-8507
Number of pages3
JournalTetrahedron Letters
Issue number46
Publication statusPublished - Nov 10 2003
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry


Dive into the research topics of 'First enantioselective total synthesis of (-)-heliannuol C'. Together they form a unique fingerprint.

Cite this