Fetal germinal matrix and intraventricular hemorrhage

Takato Morioka, Kimiaki Hashiguchi, Shinji Nagata, Yasushi Miyagi, Futoshi Mihara, Shunji Hikino, Kiyomi Tsukimori, Tomio Sasaki

Research output: Contribution to journalArticlepeer-review

26 Citations (Scopus)


Subependymal germinal matrix with intraventricular hemorrhage (GMIVH) is a common complication associated with delivery in preterm neonates but has rarely been observed in the fetus. Clinical and neuroradiological findings of 5 patients who were diagnosed as having fetal GMIVH with prenatal ultrasonographic examinations (US) and MRI, and postnatal MRI were reviewed retrospectively. During a seemingly uneventful pregnancy, fetal GMIVH occurred at approximately 30-33 weeks of gestation, with the absence of any known factor predisposing to fetal hemorrhage. Routine obstetric US revealed an intraventricular lesion in the enlarged ventricles. Prenatal MRI clearly demonstrated parenchymal change such as intracerebral hematoma adjacent to the subependymal and intraventricular hematoma, and periventricular leukomalacia as well as GMIVH. Although patients without parenchymal destruction (hemosiderin deposit alone) had a favorable neurodevelopmental outcome, encephalomalacia and periventricular leukomalacia contributed to long-term neurodevelopmental deficits. Evaluating parenchymal damage with prenatal MRI can therefore help to predict neurodevelopmental prognosis of the fetus with GMIVH.

Original languageEnglish
Pages (from-to)354-361
Number of pages8
JournalPediatric Neurosurgery
Issue number6
Publication statusPublished - Oct 2006
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health
  • Surgery
  • Clinical Neurology


Dive into the research topics of 'Fetal germinal matrix and intraventricular hemorrhage'. Together they form a unique fingerprint.

Cite this