Fetal cytomegalovirus infection manifesting as transient pancytopenia

Ryo Kiyokoba, Nobuhiro Hidaka, Yukiyo Sakata, Kazuhisa Hachisuga, Kotaro Fukushima, Kiyoko Kato

Research output: Contribution to journalArticlepeer-review


We encountered a patient with a fetal cytomegalovirus infection manifesting as pancytopenia and thoracic hypoplasia. The fetal anemia was treated by transfusion via the umbilical cord, and did not progress after 22 weeks' gestation. The neutropenia resolved spontaneously, and only thrombocytopenia was persistent at birth. The severe thoracic hypoplasia led to pulmonary hypertension and required intensive postnatal respiratory management. Our experience suggests that pancytopenia is a possible manifestation in fetuses infected with cytomegalovirus. This may be transient, resolving spontaneously during fetal life; however, caution should be taken with blood counts, particularly platelet counts, after delivery. In addition, clinicians should carefully follow the thoracic volume in cytomegalovirus-infected fetuses and consider the possibility of postnatal severe respiratory insufficiency.

Original languageEnglish
Pages (from-to)164-166
Number of pages3
JournalCongenital Anomalies
Issue number3
Publication statusPublished - Aug 1 2015

All Science Journal Classification (ASJC) codes

  • General Medicine


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