Femtosecond ionization mass spectrometry for chromatographic detection

Totaro Imasaka, Tomoko Imasaka

    Research output: Contribution to journalArticlepeer-review

    5 Citations (Scopus)


    Mass spectrometry is now in widespread use for the detection of the analytes separated by chromatography. Electron ionization is the most frequently used method in mass spectrometry. However, this ionization technique sometimes suffers from extensive fragmentation of analytes, which makes identification difficult. A photoionization technique has been developed for suppressing this fragmentation and for subsequently observing a molecular ion. A variety of lasers have been employed for the sensitive and selective ionization of organic compounds. A femtosecond laser has a high peak power and is preferential for efficient ionization as well as for suppressing fragmentation, providing valuable information concerning molecular weight and chemical structure as well. In this review, we report on applications of femtosecond ionization mass spectrometry combined with gas chromatography.

    Original languageEnglish
    Article number462023
    JournalJournal of Chromatography A
    Publication statusPublished - Apr 12 2021

    All Science Journal Classification (ASJC) codes

    • Analytical Chemistry
    • Biochemistry
    • Organic Chemistry


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