TY - JOUR
T1 - Favorable outcomes of interferon-α and ribavirin treatment for a male with subacute sclerosing panencephalitis
AU - Sonoda, Yuri
AU - Sonoda, Motoshi
AU - Yonemoto, Kousuke
AU - Sanefuji, Masafumi
AU - Taira, Ryoji
AU - Motomura, Yoshitomo
AU - Ishimura, Masataka
AU - Torisu, Hiroyuki
AU - Kira, Ryutaro
AU - Kusuhara, Koichi
AU - Sakai, Yasunari
AU - Ohga, Shouichi
N1 - Funding Information:
This study was supported by JSPS KAKENHI grant numbers JP18K15677 (Sonoda), JP19K08281 (Sakai); AMED under the grant number JP20ek0109411 , JP20wm0325002h ; a research grant for prion diseases from the Ministry of Health, Labour and Welfare of Japan ( JP20FC1054 , Sakai); The Japan Epilepsy Research Foundation , and Kawano Masanori Memorial Public Interest Incorporated Foundation for Promotion of Pediatrics (Sakai).
Publisher Copyright:
© 2021 Elsevier B.V.
PY - 2021/9/15
Y1 - 2021/9/15
N2 - Subacute sclerosing panencephalitis (SSPE) is a slow virus infection associated with mutant measles virus (MeV). The long-term outcome of antiviral treatments remains to be determined. We herein present a Japanese boy who was diagnosed with SSPE at 10 years of age. Intraventricular infusions of interferon-α effectively prevented the progress of symptoms during 14 years of follow-up period. Flow-cytometric analysis demonstrated higher proportion of T helper 17 cells (Th17, 18.2%) than healthy controls (4.8–14.5%) despite the normal subpopulation of peripheral lymphocytes. These data suggest that a group of patients with SSPE may show favorable responses to intraventricular infusions of interferon-α.
AB - Subacute sclerosing panencephalitis (SSPE) is a slow virus infection associated with mutant measles virus (MeV). The long-term outcome of antiviral treatments remains to be determined. We herein present a Japanese boy who was diagnosed with SSPE at 10 years of age. Intraventricular infusions of interferon-α effectively prevented the progress of symptoms during 14 years of follow-up period. Flow-cytometric analysis demonstrated higher proportion of T helper 17 cells (Th17, 18.2%) than healthy controls (4.8–14.5%) despite the normal subpopulation of peripheral lymphocytes. These data suggest that a group of patients with SSPE may show favorable responses to intraventricular infusions of interferon-α.
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U2 - 10.1016/j.jneuroim.2021.577656
DO - 10.1016/j.jneuroim.2021.577656
M3 - Article
C2 - 34304142
AN - SCOPUS:85111832285
SN - 0165-5728
VL - 358
JO - Journal of Neuroimmunology
JF - Journal of Neuroimmunology
M1 - 577656
ER -
