Factors related to renal dysfunction in patients with anorexia nervosa

S. Takakura, T. Nozaki, Y. Nomura, C. Koreeda, H. Urabe, K. Kawai, M. Takii, C. Kubo

Research output: Contribution to journalArticlepeer-review

21 Citations (Scopus)


OBJECTIVE: Anorexia nervosa (AN) patients were surveyed to determine which disease factors were related to AN influenced renal dysfunction. METHODS: Data were from forty-five AN patients hospitalized in our department between 1995 and 2002. The patients were classified into three groups based on the type of anorexia: restricting (n=18), self-induced vomiting (n=13), and laxative abuse (n=14). Twenty-four hour-creatinine clearance (Ccr) was calculated within two weeks of hospitalization for comparison among the three groups. RESULTS: The Ccr level of the laxative abuse group was significantly lower than that of the restricting group (65.8±31.4 ml/min vs restricting type: 104±23.3 ml/min, p=0.002). The laxative abuse group had a significantly longer duration of illness than the restricting group (p<0.0001). Multiple regression analysis revealed the duration of illness to be a risk factor for renal function deterioration in AN patients (r=0.580, p<0.001). DISCUSSION: Renal function should be carefully followed during the treatment of AN patients with a long duration of illness, especially those with long-term laxative abuse.

Original languageEnglish
Pages (from-to)73-77
Number of pages5
JournalEating and Weight Disorders
Issue number2
Publication statusPublished - 2006

All Science Journal Classification (ASJC) codes

  • Clinical Psychology
  • Psychiatry and Mental health


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