Fabry disease exhibiting recurrent stroke and persistent inflammation

Yoko Kikumoto, Yasufumi Kai, Hiroshi Morinaga, Mutsunori Iga-Murahashi, Mikitaro Matsuyama, Takashi Sasaki, Hiroki Maruyama, Masaaki Shimotori, Hirofumi Makino, Hitoshi Sugiyama, Akihiko Okayama

Research output: Contribution to journalArticlepeer-review

15 Citations (Scopus)


We describe two cases of Fabry disease in non-blood-related Japanese men, manifesting recurrent stroke even after the start of enzyme replacement therapy. Both exhibited chronic inflammation and ocular involvement with elevated levels of serum C reactive protein prior to the onset of stroke. We, therefore, suggest the association among persistent inflammation, ocular involvement and recurrent stroke in a certain subset of Fabry disease patients. Both cases received enzyme replacement therapy with no improvement in inflammatory signs or laboratory data. These cases suggest that Fabry disease should be considered in young patients with cryptogenic stroke or CNS manifestations and fever of unknown origin.

Original languageEnglish
Pages (from-to)2247-2252
Number of pages6
JournalInternal Medicine
Issue number20
Publication statusPublished - 2010
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Internal Medicine


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