TY - JOUR
T1 - Fabrication of octacalcium phosphate foam through phase conversion and its histological evaluation
AU - Sugiura, Yuki
AU - Munar, Melvin L.
AU - Ishikawa, Kunio
N1 - Funding Information:
This work was financially supported by the Strategic Promotion of Innovative Research and Development Program (16im0502004h0005), Japan Agency for Medical Research and Development , and the KAKENHI Grant for Young Scientists (B) (16K20505), Japan Society for Promotion Science.
Publisher Copyright:
© 2017
PY - 2018/2/1
Y1 - 2018/2/1
N2 - Octacalcium phosphate (OCP) foam with an interconnected porous structure was fabricated through phase conversion via a dissolution–precipitation reaction using calcium sulfate hemihydrate (CSH: CaSO4·1/2H2O) granules as precursors in a sodium dihydrogen phosphate (NaDP: NaH2PO4) solution. The diametral tensile strength and porosity of the OCP foam were 0.15 ± 0.04 MPa and 69.4% ± 0.04%, respectively. When the OCP foam was implanted into bone defects in a rabbit femur, the OCP foam showed an excellent tissue response, and the bone penetrated into the porous structure. The osteoconductivity and bone-replacement rate were significantly higher than those of an OCP compact.
AB - Octacalcium phosphate (OCP) foam with an interconnected porous structure was fabricated through phase conversion via a dissolution–precipitation reaction using calcium sulfate hemihydrate (CSH: CaSO4·1/2H2O) granules as precursors in a sodium dihydrogen phosphate (NaDP: NaH2PO4) solution. The diametral tensile strength and porosity of the OCP foam were 0.15 ± 0.04 MPa and 69.4% ± 0.04%, respectively. When the OCP foam was implanted into bone defects in a rabbit femur, the OCP foam showed an excellent tissue response, and the bone penetrated into the porous structure. The osteoconductivity and bone-replacement rate were significantly higher than those of an OCP compact.
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U2 - 10.1016/j.matlet.2017.10.051
DO - 10.1016/j.matlet.2017.10.051
M3 - Article
AN - SCOPUS:85031785762
SN - 0167-577X
VL - 212
SP - 28
EP - 31
JO - Materials Letters
JF - Materials Letters
ER -