Fabrication of interconnected pore forming α-tricalcium phosphate foam granules cement

Khairul Anuar Shariff, Kanji Tsuru, Kunio Ishikawa

Research output: Contribution to journalArticlepeer-review

19 Citations (Scopus)


Interconnected pore forming calcium phosphate cement is useful for the reconstruction of bone defects as well as scaffold fabrication in tissue engineering. In this study, interconnected pore forming calcium phosphate cement was fabricated using α-tricalcium phosphate (α-TCP) foam granules. When α-TCP foam granules were mixed with acidic calcium phosphate solution prepared from monocalcium phosphate monohydrate (MCPM) and phosphoric acid solution, brushite crystals were precipitated. These crystals bridged the α-TCP foam granules immediately upon mixing. As a result of the brushite bridge between the α-TCP foam granules, fully interconnected macroporous α-TCP was obtained. The amount of brushite precipitate and the mechanical strength of the set cement increased with acidic calcium phosphate concentration.

Original languageEnglish
Pages (from-to)838-845
Number of pages8
JournalJournal of Biomaterials Applications
Issue number6
Publication statusPublished - Jan 1 2016

All Science Journal Classification (ASJC) codes

  • Biomaterials
  • Biomedical Engineering


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