Fabrication and characterization of biodegradable nano-particles containing a drug for DDS by self-organized precipitation method

Daisuke Ohsato; Masaru Tanaka; Sadaaki Yamamoto; Takeshi Higuchi; Hiroshi Yabu; Masatsugu Shimomura

Fabrication and characterization of biodegradable nano-particles containing a drug for DDS by self-organized precipitation method

Daisuke Ohsato, Masaru Tanaka, Sadaaki Yamamoto, Takeshi Higuchi, Hiroshi Yabu, Masatsugu Shimomura

Research output: Contribution to conference › Paper › peer-review

Abstract

Recently, we have reported the preparation of nano-particles by mixing a poor solvent into a solution of polymer, and evaporating a good solvent. In this report, biodegradable polymer particles containing pyrene (Py) as a model compound of hydrophobic drug were fabricated. The morphology of particles was observed by FE-SEM. The content of Py in the particles was determined as c.a. 10 wt%. By measuring fluorescence spectra, we found that the Py in the particles was distributed in the state of monomer. Py was released about 80% over 200 hours in 10 mM sodium phosphate buffer (pH7.4).

Original language	English
Pages	1948
Number of pages	1
Publication status	Published - 2006
Externally published	Yes
Event	55th SPSJ Annual Meeting - Nagoya, Japan Duration: May 24 2006 → May 26 2006

Other

Other	55th SPSJ Annual Meeting
Country/Territory	Japan
City	Nagoya
Period	5/24/06 → 5/26/06

All Science Journal Classification (ASJC) codes

Engineering(all)

Cite this

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title = "Fabrication and characterization of biodegradable nano-particles containing a drug for DDS by self-organized precipitation method",

abstract = "Recently, we have reported the preparation of nano-particles by mixing a poor solvent into a solution of polymer, and evaporating a good solvent. In this report, biodegradable polymer particles containing pyrene (Py) as a model compound of hydrophobic drug were fabricated. The morphology of particles was observed by FE-SEM. The content of Py in the particles was determined as c.a. 10 wt%. By measuring fluorescence spectra, we found that the Py in the particles was distributed in the state of monomer. Py was released about 80% over 200 hours in 10 mM sodium phosphate buffer (pH7.4).",

author = "Daisuke Ohsato and Masaru Tanaka and Sadaaki Yamamoto and Takeshi Higuchi and Hiroshi Yabu and Masatsugu Shimomura",

year = "2006",

language = "English",

pages = "1948",

note = "55th SPSJ Annual Meeting ; Conference date: 24-05-2006 Through 26-05-2006",

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TY - CONF

T1 - Fabrication and characterization of biodegradable nano-particles containing a drug for DDS by self-organized precipitation method

AU - Ohsato, Daisuke

AU - Tanaka, Masaru

AU - Yamamoto, Sadaaki

AU - Higuchi, Takeshi

AU - Yabu, Hiroshi

AU - Shimomura, Masatsugu

PY - 2006

Y1 - 2006

N2 - Recently, we have reported the preparation of nano-particles by mixing a poor solvent into a solution of polymer, and evaporating a good solvent. In this report, biodegradable polymer particles containing pyrene (Py) as a model compound of hydrophobic drug were fabricated. The morphology of particles was observed by FE-SEM. The content of Py in the particles was determined as c.a. 10 wt%. By measuring fluorescence spectra, we found that the Py in the particles was distributed in the state of monomer. Py was released about 80% over 200 hours in 10 mM sodium phosphate buffer (pH7.4).

AB - Recently, we have reported the preparation of nano-particles by mixing a poor solvent into a solution of polymer, and evaporating a good solvent. In this report, biodegradable polymer particles containing pyrene (Py) as a model compound of hydrophobic drug were fabricated. The morphology of particles was observed by FE-SEM. The content of Py in the particles was determined as c.a. 10 wt%. By measuring fluorescence spectra, we found that the Py in the particles was distributed in the state of monomer. Py was released about 80% over 200 hours in 10 mM sodium phosphate buffer (pH7.4).

UR - http://www.scopus.com/inward/record.url?scp=33749840281&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33749840281&partnerID=8YFLogxK

M3 - Paper

AN - SCOPUS:33749840281

SP - 1948

T2 - 55th SPSJ Annual Meeting

Y2 - 24 May 2006 through 26 May 2006

ER -

Fabrication and characterization of biodegradable nano-particles containing a drug for DDS by self-organized precipitation method

Abstract

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All Science Journal Classification (ASJC) codes

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