F-box proteins and cancer

Kanae Yumimoto, Yuhei Yamauchi, Keiichi I. Nakayama

Research output: Contribution to journalReview articlepeer-review

31 Citations (Scopus)


Controlled protein degradation is essential for the operation of a variety of cellular processes including cell division, growth, and differentiation. Identification of the relations between ubiquitin ligases and their substrates is key to understanding the molecular basis of cancer development and to the discovery of novel targets for cancer therapeutics. F-box proteins function as the substrate recognition subunits of S-phase kinase-associated protein 1 (SKP1)−Cullin1 (CUL1)−F-box protein (SCF) ubiquitin ligase complexes. Here, we summarize the roles of specific Fbox proteins that have been shown to function as tumor promoters or suppressors. We also highlight proto-oncoproteins that are targeted for ubiquitylation by multiple F-box proteins, and discuss how these F-box proteins are deployed to regulate their cognate substrates in various situations.

Original languageEnglish
Article number1249
Issue number5
Publication statusPublished - May 2020

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research


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