Extraosseous accumulation of 99mTc-HMDP to radiation nephropathy, mimicking recurrent neuroblastoma

Koichiro Abe, Masayuki Sasaki, Yasuo Kuwabara, Hirofumi Koga, Shingo Baba, Koichiro Kaneko, Kazutaka Hayashi, Yoshiyuki Shioyama, Tatsuro Tajiri, Sachiyo Suita, Hiroshi Honda

Research output: Contribution to journalReview articlepeer-review

2 Citations (Scopus)


Objective: The aim of this study is to clarify the period of extraosseous accumulation of 99mTc-hydroxymethylenediphosphonate (HMDP) to radiation nephropathy mimicking recurrent or remnant neuroblastoma in the pararenal region. Methods: We reviewed five neuroblastoma and one ganglioneuroblastoma patients (2 boys and 4 girls aged 1-9 years) who underwent 99mTc-HMDP bone scintigraphies periodically before and after radiation therapy. Results: Increased renal uptake coincident with the radiation port appeared in 5 of 6 patients from O to 3 months (mean 1.7 months), and persisted up to 7 months after the completion of radiotherapy. Renal uptake of 99mTc-HMDP was gradually decreased, and eventually became accumulation defects in 5 of 6 patients from 6 to 17 months (mean 8.9 months) after radiotherapy. Conclusion: When extraosseous accumulation is found after radiation therapy in neuroblastoma patients, radiation nephropathy would be a candidate in the differential diagnosis besides recurrent or remnant tumor.

Original languageEnglish
Pages (from-to)35-40
Number of pages6
JournalAnnals of Nuclear Medicine
Issue number1
Publication statusPublished - Feb 2005

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging


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