TY - JOUR
T1 - Extracellular volume fraction determined by equilibrium contrast-enhanced computed tomography
T2 - correlation with histopathological findings in gastric cancer
AU - Nishimuta, Yusuke
AU - Tsurumaru, Daisuke
AU - Kai, Satohiro
AU - Maehara, Junki
AU - Asayama, Yoshiki
AU - Oki, Eiji
AU - Ishigami, Kousei
N1 - Publisher Copyright:
© 2023, The Author(s).
PY - 2023/7
Y1 - 2023/7
N2 - Purpose: To assess the relationship between histopathological features of gastric cancer and the extracellular volume fraction (ECV) measured by preoperative equilibrium contrast-enhanced computed tomography (CECT). Materials and methods: The study group consisted of 66 patients with surgically resected gastric adenocarcinoma who underwent preoperative multiphasic CECT. Tumor ECVs were calculated using region-of-interest measurements within the gastric cancer and aorta of each case on unenhanced and equilibrium-phase images. The relationship between the mean ECV values and clinicopathological parameters was examined by univariate analysis. Parameters showing a significant difference in the former test were further tested by linear regression and receiver operating characteristic (ROC) curve analyses. Results: In the univariate analysis, the values of venous invasion (p = 0.0487) and tumor infiltration (INF) pattern (p < 0.0001) were significantly correlated with the tumor ECV. INF was significantly correlated (β = 0.57, p < 0.0001) in the linear regression analysis. The tumor ECV showed better diagnostic accuracy for predicting INF (INFa/b vs INFc), and the area under the ROC curve value was 0.89. Conclusion: Tumor ECV determined by equilibrium CECT is significantly correlated with the pathological INF of gastric cancer.
AB - Purpose: To assess the relationship between histopathological features of gastric cancer and the extracellular volume fraction (ECV) measured by preoperative equilibrium contrast-enhanced computed tomography (CECT). Materials and methods: The study group consisted of 66 patients with surgically resected gastric adenocarcinoma who underwent preoperative multiphasic CECT. Tumor ECVs were calculated using region-of-interest measurements within the gastric cancer and aorta of each case on unenhanced and equilibrium-phase images. The relationship between the mean ECV values and clinicopathological parameters was examined by univariate analysis. Parameters showing a significant difference in the former test were further tested by linear regression and receiver operating characteristic (ROC) curve analyses. Results: In the univariate analysis, the values of venous invasion (p = 0.0487) and tumor infiltration (INF) pattern (p < 0.0001) were significantly correlated with the tumor ECV. INF was significantly correlated (β = 0.57, p < 0.0001) in the linear regression analysis. The tumor ECV showed better diagnostic accuracy for predicting INF (INFa/b vs INFc), and the area under the ROC curve value was 0.89. Conclusion: Tumor ECV determined by equilibrium CECT is significantly correlated with the pathological INF of gastric cancer.
KW - Computed tomography
KW - Extracellular volume fraction
KW - Gastric cancer
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U2 - 10.1007/s11604-023-01393-3
DO - 10.1007/s11604-023-01393-3
M3 - Article
C2 - 36735208
AN - SCOPUS:85147367224
SN - 1867-1071
VL - 41
SP - 752
EP - 759
JO - Japanese Journal of Radiology
JF - Japanese Journal of Radiology
IS - 7
ER -
