Extended linkage disequilibrium in noncoding regions in a conifer, Cryptomeria Japonica

Etsuko Moritsuka; Yosuke Hisataka; Miho Tamura; Kentaro Uchiyama; Atsushi Watanabe; Yoshihiko Tsumura; Hidenori Tachida

doi:10.1534/genetics.111.136697

Extended linkage disequilibrium in noncoding regions in a conifer, Cryptomeria Japonica

Etsuko Moritsuka, Yosuke Hisataka, Miho Tamura, Kentaro Uchiyama, Atsushi Watanabe, Yoshihiko Tsumura, Hidenori Tachida

Research output: Contribution to journal › Comment/debate › peer-review

28 Citations (Scopus)

Abstract

We measured linkage disequilibrium in mostly noncoding regions of Cryptomeria japonica, a conifer belonging to Cupressaceae. Linkage disequilibrium was extensive and did not decay even at a distance of 100 kb. The average estimate of the population recombination rate per base pair was 1.55×10 ^-5 and was <1/70 of that in the coding regions. We discuss the impact of low recombination rates in a large part of the genome on association studies.

Original language	English
Pages (from-to)	1145-1148
Number of pages	4
Journal	Genetics
Volume	190
Issue number	3
DOIs	https://doi.org/10.1534/genetics.111.136697
Publication status	Published - Mar 2012

All Science Journal Classification (ASJC) codes

Genetics

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10.1534/genetics.111.136697

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title = "Extended linkage disequilibrium in noncoding regions in a conifer, Cryptomeria Japonica",

abstract = "We measured linkage disequilibrium in mostly noncoding regions of Cryptomeria japonica, a conifer belonging to Cupressaceae. Linkage disequilibrium was extensive and did not decay even at a distance of 100 kb. The average estimate of the population recombination rate per base pair was 1.55×10 -5 and was <1/70 of that in the coding regions. We discuss the impact of low recombination rates in a large part of the genome on association studies.",

author = "Etsuko Moritsuka and Yosuke Hisataka and Miho Tamura and Kentaro Uchiyama and Atsushi Watanabe and Yoshihiko Tsumura and Hidenori Tachida",

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AU - Moritsuka, Etsuko

AU - Hisataka, Yosuke

AU - Tamura, Miho

AU - Uchiyama, Kentaro

AU - Watanabe, Atsushi

AU - Tsumura, Yoshihiko

AU - Tachida, Hidenori

PY - 2012/3

Y1 - 2012/3

N2 - We measured linkage disequilibrium in mostly noncoding regions of Cryptomeria japonica, a conifer belonging to Cupressaceae. Linkage disequilibrium was extensive and did not decay even at a distance of 100 kb. The average estimate of the population recombination rate per base pair was 1.55×10 -5 and was <1/70 of that in the coding regions. We discuss the impact of low recombination rates in a large part of the genome on association studies.

AB - We measured linkage disequilibrium in mostly noncoding regions of Cryptomeria japonica, a conifer belonging to Cupressaceae. Linkage disequilibrium was extensive and did not decay even at a distance of 100 kb. The average estimate of the population recombination rate per base pair was 1.55×10 -5 and was <1/70 of that in the coding regions. We discuss the impact of low recombination rates in a large part of the genome on association studies.

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EP - 1148

JO - Genetics

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Extended linkage disequilibrium in noncoding regions in a conifer, Cryptomeria Japonica

Abstract

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