Expression profile of class I histone deacetylases in human cancer tissues

Masamune Nakagawa, Yoshinao Oda, Takashi Eguchi, Shin Ichi Aishima, Takashi Yao, Fumihito Hosoi, Yuji Basaki, Mayumi Ono, Michihiko Kuwano, Masao Tanaka, Masazumi Tsuneyoshi

Research output: Contribution to journalArticlepeer-review

302 Citations (Scopus)


Histone deacetylase (HDAC) activity is one of the widely used and well-established mechanisms for regulation of various genes in cancer. To identify which subtype of class I HDACs are overexpressed in cancers, we analyzed the expression of class I HDAC isotypes composed of HDAC1, 2, 3 and 8 in several cell lines and human cancer tissues, including cancer of the stomach, esophagus, colon, prostate, breast, ovary, lung, pancreas and thyroid. The results showed that >75% of human cancer tissues and their corresponding non-cancerous epithelium showed high expression of these class I HDACs. However, the immunoreactivity of HDAC8 in both prostatic cancer tissue and non-cancerous prostate glands was lower than that in other cancer tissues. Furthermore, 5-40% of cancer tissues overexpressed class I HDACs, when compared with normal epithelium. The results suggest the potential usefulness of HDAC inhibitors for the treatment of a wide variety of human cancers.

Original languageEnglish
Pages (from-to)769-774
Number of pages6
JournalOncology reports
Issue number4
Publication statusPublished - Oct 2007

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research


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