TY - JOUR
T1 - Expression of TrkB and BDNF is associated with poor prognosis in non-small cell lung cancer
AU - Okamura, Kyoko
AU - Harada, Taishi
AU - Wang, Shuo
AU - Ijichi, Kayo
AU - Furuyama, Kazuto
AU - Koga, Takaomi
AU - Okamoto, Tatsuro
AU - Takayama, Koichi
AU - Yano, Tokujiro
AU - Nakanishi, Yoichi
N1 - Funding Information:
This study was supported by research fund in Research Institute for Diseases of the Chest .
PY - 2012/10
Y1 - 2012/10
N2 - High expression levels of TrkB and BDNF are associated with aggressive malignant behavior in tumor cells and a poor prognosis in patients with various types of cancer. In this study, we aimed to identify the relationship between TrkB and BDNF expression and clinicopathological variables and prognosis in non-small cell lung cancer (NSCLC). We evaluated TrkB and BDNF expression in the tumor cells of 102 NSCLC patients by immunohistochemistry. Out of all clinicopathological factors examined, only vascular invasion was significantly correlated with TrkB (P= 0.010) and BDNF (P= 0.015) expression. TrkB-positive tumors had significantly worse disease-free survival (P= 0.0094) and overall survival (P= 0.0019) than TrkB-negative tumors, and TrkB expression was an independent prognostic factor for disease-free survival (HR 3.735, 95%C.I. 1.560-11.068, P= 0.002) and overall survival (HR 4.335, 95%C.I. 1.534-15.963, P= 0.004) in multivariate analysis. Finally, our analysis revealed that co-expression of TrkB and BDNF conferred poorer prognosis compared with overexpression of either protein alone. Our results indicate that expression of TrkB and BDNF is associated with poor prognosis in NSCLC patients.
AB - High expression levels of TrkB and BDNF are associated with aggressive malignant behavior in tumor cells and a poor prognosis in patients with various types of cancer. In this study, we aimed to identify the relationship between TrkB and BDNF expression and clinicopathological variables and prognosis in non-small cell lung cancer (NSCLC). We evaluated TrkB and BDNF expression in the tumor cells of 102 NSCLC patients by immunohistochemistry. Out of all clinicopathological factors examined, only vascular invasion was significantly correlated with TrkB (P= 0.010) and BDNF (P= 0.015) expression. TrkB-positive tumors had significantly worse disease-free survival (P= 0.0094) and overall survival (P= 0.0019) than TrkB-negative tumors, and TrkB expression was an independent prognostic factor for disease-free survival (HR 3.735, 95%C.I. 1.560-11.068, P= 0.002) and overall survival (HR 4.335, 95%C.I. 1.534-15.963, P= 0.004) in multivariate analysis. Finally, our analysis revealed that co-expression of TrkB and BDNF conferred poorer prognosis compared with overexpression of either protein alone. Our results indicate that expression of TrkB and BDNF is associated with poor prognosis in NSCLC patients.
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U2 - 10.1016/j.lungcan.2012.07.011
DO - 10.1016/j.lungcan.2012.07.011
M3 - Article
C2 - 22906736
AN - SCOPUS:84866181540
SN - 0169-5002
VL - 78
SP - 100
EP - 106
JO - Lung Cancer
JF - Lung Cancer
IS - 1
ER -
