TY - JOUR
T1 - Expression of transient receptor potential vanilloid (TRPV) 1, 2, 3, and 4 in mouse inner ear
AU - Ishibashi, Takuya
AU - Takumida, Masaya
AU - Akagi, Nana
AU - Hirakawa, Katsuhiro
AU - Anniko, Matti
N1 - Funding Information:
This study was supported by a Health and Labor Science Research Grant for Research on Specific Disease (Vestibular Disorders) from the Ministry of Health, Labor and Welfare, Japan (2007), a Grant-in-aid for Scientific Research (19591972) provided by the Japanese Ministry of Education, Science and Culture, and also by the Swedish Medical Research Council (grant no. 17X-7305).
PY - 2008
Y1 - 2008
N2 - Conclusion. It is suggested that transient receptor potential vanilloids (TRPVs) may play a functional role in cell physiology and TRPV-4 and -2 may play an important part in fluid homeostasis in the inner ear. Objective. Expression of TRPV-1, -2, -3, and -4 in the normal mouse inner ear was studied. Materials and methods. CBA/J mice were used in this study. The localization of TRPV-1, -2, -3, and -4 in the inner ear, i.e. cochlea, vestibular end organs, and endolymphatic sac, was investigated by immunohistochemistry. Results. TRPV-1, -2, and -3 were co-expressed in hair cells and supporting cells of the organ of Corti, in spiral ganglion cells, sensory cells in vestibular end organs, vestibular ganglion cells, and sensory nerve fibers. TRPV-2 was also detected in the stria vascularis, dark cells, and endolymphatic sac. TRPV-4 was expressed in hair cells and supporting cells of the organ of Corti, in marginal cells of the stria vascularis, spiral ganglion cells, vestibular sensory cells, vestibular dark cells, vestibular ganglion cells, and epithelial cells of the endolymphatic sac.
AB - Conclusion. It is suggested that transient receptor potential vanilloids (TRPVs) may play a functional role in cell physiology and TRPV-4 and -2 may play an important part in fluid homeostasis in the inner ear. Objective. Expression of TRPV-1, -2, -3, and -4 in the normal mouse inner ear was studied. Materials and methods. CBA/J mice were used in this study. The localization of TRPV-1, -2, -3, and -4 in the inner ear, i.e. cochlea, vestibular end organs, and endolymphatic sac, was investigated by immunohistochemistry. Results. TRPV-1, -2, and -3 were co-expressed in hair cells and supporting cells of the organ of Corti, in spiral ganglion cells, sensory cells in vestibular end organs, vestibular ganglion cells, and sensory nerve fibers. TRPV-2 was also detected in the stria vascularis, dark cells, and endolymphatic sac. TRPV-4 was expressed in hair cells and supporting cells of the organ of Corti, in marginal cells of the stria vascularis, spiral ganglion cells, vestibular sensory cells, vestibular dark cells, vestibular ganglion cells, and epithelial cells of the endolymphatic sac.
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U2 - 10.1080/00016480801938958
DO - 10.1080/00016480801938958
M3 - Article
C2 - 18607942
AN - SCOPUS:57349126240
SN - 0001-6489
VL - 128
SP - 1286
EP - 1293
JO - Acta Oto-Laryngologica
JF - Acta Oto-Laryngologica
IS - 12
ER -