Expression of Set-α during morphogenesis of mouse lower first molar

Haruyoshi Yamaza, Kou Matsuo, Ieyoshi Kobayashi, Hiroko Wada, Tamotsu Kiyoshima, Merina Akhtar, Yukiko Ishibashi, Takako Sakai, Akifumi Akamine, Hidetaka Sakai

Research output: Contribution to journalArticlepeer-review

12 Citations (Scopus)


The detailed in situ expression pattern of the Set-α gene has been studied. Previously we showed that Set-α is a differentially expressed gene in the embryonic mouse mandible at day 10.5 (E10.5) gestational age. Cells expressing Set-α were widely distributed in both the epithelial and underlying ectomesenchymal cells at E10.5. At E12, they were slightly aggregated in an area where tooth germ of the lower first molar is estimated to be formed. At E13.5, Set-α was strongly expressed in the tooth germ. At the cap stage, Set-α was expressed in the enamel organ and dental papilla. At the bell stage, Set-α was distinctly expressed in the inner enamel epithelial and dental papilla cells facing the inner enamel epithelial layer, which were intended to differentiate into ameloblasts and odontoblasts, respectively. Interestingly, Set-α was also expressed in several embryonic craniofacial tissues derived from the ectoderm. This study is the first report that Set-α is distinctly expressed in the developing tooth germ, and suggests that Set-α plays an important role in both the initiation and the growth of the tooth germ, as well as in the differentiation of ameloblasts and odontoblasts.

Original languageEnglish
Pages (from-to)437-441
Number of pages5
JournalHistochemical Journal
Issue number8
Publication statusPublished - 2001

All Science Journal Classification (ASJC) codes

  • Anatomy
  • Cell Biology


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