Expression of ornithine decarboxylase mRNA and c-myc mRNA in breast tumours

Koshi Mimori; Masaki Mori; Takeshi Shiraishi; Shinji Tanaka; Masaru Haraguchi; Hiroaki Ueo; Chiaki Shirasaka; Tsuyoshi Akiyoshi

doi:10.3892/ijo.12.3.597

Expression of ornithine decarboxylase mRNA and c-myc mRNA in breast tumours

Koshi Mimori, Masaki Mori, Takeshi Shiraishi, Shinji Tanaka, Masaru Haraguchi, Hiroaki Ueo, Chiaki Shirasaka, Tsuyoshi Akiyoshi

Surgery

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Abstract

We examined the expression of ornithine decarboxylase (ODC) mRNA in 53 female cases of breast cancer by a reverse transcriptase-polymerase chain reaction (RT-PCR) assay to determine the clinicopathologic significance of its expression. A significantly higher expression of ODC mRNA was, observed in younger patients than in older patients. The patients with a larger sized tumour possessed a significantly higher expression of ODC mRNA. In addition, the cases with a poor prognosis showed significantly higher expression of ODC. Previous studies have reported in vivo and in vitro correlation between the expression of ODC and c-myc genes in human carcinomas. We disclosed a significant correlation between these genes in primary breast carcinomas. We conclude that the expression of ODC may potentially be a new biological marker for breast carcinoma.

Original language	English
Pages (from-to)	597-601
Number of pages	5
Journal	International journal of oncology
Volume	12
Issue number	3
DOIs	https://doi.org/10.3892/ijo.12.3.597
Publication status	Published - Mar 1998

All Science Journal Classification (ASJC) codes

Oncology
Cancer Research

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3892/ijo.12.3.597

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title = "Expression of ornithine decarboxylase mRNA and c-myc mRNA in breast tumours",

abstract = "We examined the expression of ornithine decarboxylase (ODC) mRNA in 53 female cases of breast cancer by a reverse transcriptase-polymerase chain reaction (RT-PCR) assay to determine the clinicopathologic significance of its expression. A significantly higher expression of ODC mRNA was, observed in younger patients than in older patients. The patients with a larger sized tumour possessed a significantly higher expression of ODC mRNA. In addition, the cases with a poor prognosis showed significantly higher expression of ODC. Previous studies have reported in vivo and in vitro correlation between the expression of ODC and c-myc genes in human carcinomas. We disclosed a significant correlation between these genes in primary breast carcinomas. We conclude that the expression of ODC may potentially be a new biological marker for breast carcinoma.",

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T1 - Expression of ornithine decarboxylase mRNA and c-myc mRNA in breast tumours

AU - Mimori, Koshi

AU - Mori, Masaki

AU - Shiraishi, Takeshi

AU - Tanaka, Shinji

AU - Haraguchi, Masaru

AU - Ueo, Hiroaki

AU - Shirasaka, Chiaki

AU - Akiyoshi, Tsuyoshi

PY - 1998/3

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AB - We examined the expression of ornithine decarboxylase (ODC) mRNA in 53 female cases of breast cancer by a reverse transcriptase-polymerase chain reaction (RT-PCR) assay to determine the clinicopathologic significance of its expression. A significantly higher expression of ODC mRNA was, observed in younger patients than in older patients. The patients with a larger sized tumour possessed a significantly higher expression of ODC mRNA. In addition, the cases with a poor prognosis showed significantly higher expression of ODC. Previous studies have reported in vivo and in vitro correlation between the expression of ODC and c-myc genes in human carcinomas. We disclosed a significant correlation between these genes in primary breast carcinomas. We conclude that the expression of ODC may potentially be a new biological marker for breast carcinoma.

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Expression of ornithine decarboxylase mRNA and c-myc mRNA in breast tumours

Abstract

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