Expression of microsomal prostaglandin E synthase-1 in human hepatocelluar carcinoma

Yasushi Takii, Seigo Abiru, Hikaru Fujioka, Minoru Nakamura, Atsumasa Komori, Masahiro Ito, Ken Taniguchi, Manabu Daikoku, Yumi Meda, Kazuyuki Ohata, Koji Yano, Shinji Shimoda, Hiroshi Yatsuhashi, Hiromi Ishibashi, Kiyoshi Migita

Research output: Contribution to journalArticlepeer-review

21 Citations (Scopus)


Background/Aims: The objective of this study was to evaluate the expression of microsomal prostaglandin E synthase-1 (mPGES-1) in hepatocellular carcinoma (HCC) tissues. Methods: Forty surgically resected HCC tissues with adjacent non-tumorous liver tissues and 14 surgically resected, histologically normal liver tissues were used. The immunohistochemical expressions of the mPGES-1 protein in these HCC tissues and normal control livers were analysed. mPGES-1 mRNA expression was also analysed by the real-time polymerase chain reaction method using the same tissues. Results: Microsomal prostaglandin E synthase-1 was not expressed in hepatocytes but instead in vascular endothelial cells and bile duct epithelial cells in normal liver tissues. The mPGES-1 expression in HCC tissues was significantly greater than its expression in the non-tumorous tissues. All types of HCC expressed more mPGES-1 than normal or hepatitis livers, and the levels of mPGES-1 expression in poorly differentiated HCC were similar to the levels in well-differentiated HCC. The mPGES-1 mRNA expression paralleled its protein expression in these tumorous and non-tumorous tissues. Conclusions: The present study is the first to demonstrate a high expression of mPGES-1 in well-differentiated HCC as well as in poorly differentiated HCC. These findings suggest that mPGES-1 may play a role in the advanced as well as early stage of hepatocarcinogenesis.

Original languageEnglish
Pages (from-to)989-996
Number of pages8
JournalLiver International
Issue number7
Publication statusPublished - Sept 2007

All Science Journal Classification (ASJC) codes

  • Hepatology


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