TY - JOUR
T1 - Expression of lysophosphatidic acid receptors and vascular endothelial growth factor mediating lysophosphatidic acid in the development of human ovarian cancer
AU - Fujita, Takuji
AU - Miyamoto, Shingo
AU - Onoyama, Ichiro
AU - Sonoda, Kenzo
AU - Mekada, Eisuke
AU - Nakano, Hitoo
N1 - Funding Information:
We thank Mrs L. Saza for helpful discussions. This work was supported in part by a grant-in-aid for cancer research from the Ministry of Health and Welfare of Japan (numbers: 13671727, 13671728, and 14571568). This work was in part done at the Station for Collaborative Research and at the Morphology Core, Graduate School of Medical Sciences, Kyushu University.
PY - 2003/3/31
Y1 - 2003/3/31
N2 - Lysophosphatidic acid (LPA) receptors including LPA1, LPA2, and LPA3 mediate lysophosphatidic acid signals. We analyzed the expression of LPA receptors, vascular endothelial growth factor (VEGF), and interleukin-8 in 97 patients from normal ovary to ovarian cancer, using reverse transcription polymerase chain reaction. LPA2, LPA3, and VEGF expression ratios significantly increased in cancer, compared to those in non-cancerous state (P < 0.05). A significant correlation in the expression ratios between LPA2 or LPA3 and VEGF was found (γ = 0.617, P < 0.0001; γ = 0.431, P < 0.001) in patients with cancer. These results suggested that LPA2 and LPA3 may be involved in VEGF expression mediated by LPA signals in human ovarian oncogenesis.
AB - Lysophosphatidic acid (LPA) receptors including LPA1, LPA2, and LPA3 mediate lysophosphatidic acid signals. We analyzed the expression of LPA receptors, vascular endothelial growth factor (VEGF), and interleukin-8 in 97 patients from normal ovary to ovarian cancer, using reverse transcription polymerase chain reaction. LPA2, LPA3, and VEGF expression ratios significantly increased in cancer, compared to those in non-cancerous state (P < 0.05). A significant correlation in the expression ratios between LPA2 or LPA3 and VEGF was found (γ = 0.617, P < 0.0001; γ = 0.431, P < 0.001) in patients with cancer. These results suggested that LPA2 and LPA3 may be involved in VEGF expression mediated by LPA signals in human ovarian oncogenesis.
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U2 - 10.1016/S0304-3835(02)00713-9
DO - 10.1016/S0304-3835(02)00713-9
M3 - Article
C2 - 12668280
AN - SCOPUS:0037474724
SN - 0304-3835
VL - 192
SP - 161
EP - 169
JO - Cancer Letters
JF - Cancer Letters
IS - 2
ER -
