Expression of a liver-specific function by a hepatoblastoma cell line cocultured with three-dimensional endothelialized tubes in collagen gels

Takayuki Takei; Shinji Sakai; Hiroyuki Ijima; Koei Kawakami

doi:10.1263/jbb.103.200

Expression of a liver-specific function by a hepatoblastoma cell line cocultured with three-dimensional endothelialized tubes in collagen gels

Takayuki Takei, Shinji Sakai, Hiroyuki Ijima, Koei Kawakami

Molecular and Biochemical Systems Engineering

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Abstract

A human hepatoblastoma cell line, Hep G2, showed albumin production activity, a hepatic function, when cocultured with three-dimensional endothelialized tubes in collagen gels. The albumin production rate of the collagen-based liver-like constructs increased with increasing length of the endothelialized tube in the construct.

Original language	English
Pages (from-to)	200-202
Number of pages	3
Journal	Journal of Bioscience and Bioengineering
Volume	103
Issue number	2
DOIs	https://doi.org/10.1263/jbb.103.200
Publication status	Published - Feb 2007

All Science Journal Classification (ASJC) codes

Biotechnology
Bioengineering
Applied Microbiology and Biotechnology

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title = "Expression of a liver-specific function by a hepatoblastoma cell line cocultured with three-dimensional endothelialized tubes in collagen gels",

abstract = "A human hepatoblastoma cell line, Hep G2, showed albumin production activity, a hepatic function, when cocultured with three-dimensional endothelialized tubes in collagen gels. The albumin production rate of the collagen-based liver-like constructs increased with increasing length of the endothelialized tube in the construct.",

author = "Takayuki Takei and Shinji Sakai and Hiroyuki Ijima and Koei Kawakami",

note = "Funding Information: This work was supported in part by a Grant-in-Aid for Scientific Research from the Japan Society for the Promotion Science, no. 9432, 2006, and a Grant-in-Aid for Scientific Research for the 21st Century COE Program “Functional Innovation of Molecular Informatics” from the Ministry of Education, Culture, Sports, Science and Technology of Japan.",

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AU - Takei, Takayuki

AU - Sakai, Shinji

AU - Ijima, Hiroyuki

AU - Kawakami, Koei

N1 - Funding Information: This work was supported in part by a Grant-in-Aid for Scientific Research from the Japan Society for the Promotion Science, no. 9432, 2006, and a Grant-in-Aid for Scientific Research for the 21st Century COE Program “Functional Innovation of Molecular Informatics” from the Ministry of Education, Culture, Sports, Science and Technology of Japan.

PY - 2007/2

Y1 - 2007/2

N2 - A human hepatoblastoma cell line, Hep G2, showed albumin production activity, a hepatic function, when cocultured with three-dimensional endothelialized tubes in collagen gels. The albumin production rate of the collagen-based liver-like constructs increased with increasing length of the endothelialized tube in the construct.

AB - A human hepatoblastoma cell line, Hep G2, showed albumin production activity, a hepatic function, when cocultured with three-dimensional endothelialized tubes in collagen gels. The albumin production rate of the collagen-based liver-like constructs increased with increasing length of the endothelialized tube in the construct.

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Expression of a liver-specific function by a hepatoblastoma cell line cocultured with three-dimensional endothelialized tubes in collagen gels

Abstract

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