Abstract
The expression and cellular localization of αβ-crystallin during rat renal development was studied by Northern blot analysis and by immunocytochemistry. Northern blotting of total RNA extracted from whole kidneys revealed that the messenger RNA for αβ-crystallin rapidly increased after birth to reach adult levels by 20 days. At the same time, immunohistochemistry for αβ-crystallin demonstrated that the prominent elongation of Henle's loop during the first 10 days of life was accompanied by increased αβ-crystallin expression. Thus, the development of αβ-crystallin expression is correlated temporally with the acquisition of tubule function in early post-natal life.
| Original language | English |
|---|---|
| Pages (from-to) | 52-56 |
| Number of pages | 5 |
| Journal | Kidney International |
| Volume | 40 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Jul 1991 |
All Science Journal Classification (ASJC) codes
- Nephrology