Experimental evidence for the efficacy of combined therapy of CPT-11 and hyperthermia for squamous cell carcinoma of the esophagus

Tadahiro Nozoe; Mitsuhiro Yasuda; Masayuki Honda; Sadaaki Imutsuka; Daisuke Korenaga

Experimental evidence for the efficacy of combined therapy of CPT-11 and hyperthermia for squamous cell carcinoma of the esophagus

Tadahiro Nozoe, Mitsuhiro Yasuda, Masayuki Honda, Sadaaki Imutsuka, Daisuke Korenaga

Faculty of Medical Sciences

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

Background/Aims: The aim of the current study was to show an anti-tumor effect for esophageal squamous carcinoma cells derived from a combination of hyperthermia and CPT-11, which would ultimately lead to the clinical usage of this therapeutic modality for patients with squamous cell carcinoma of the esophagus. Methodology: Survival fraction of esophageal squamous carcinoma cells after administrating SN-38, active metabolite of CPT-11, and combination of hyperthermia and SN-38 was compared using data measured by MTT assay. Results: Reduction of cell survival fraction derived by simultaneous induction of hyperthermia and SN-38, in many combinations of the temperature and charging period, was significantly greater than that acquired by SN-38 alone. Conclusions: Combination of hyperthermia and CPT-11 can exert a synergic anti-tumor efficacy for SCC of the esophagus.

Original language	English
Pages (from-to)	2272-2275
Number of pages	4
Journal	Hepato-gastroenterology
Volume	54
Issue number	80
Publication status	Published - Dec 1 2007

All Science Journal Classification (ASJC) codes

Hepatology
Gastroenterology

Cite this

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title = "Experimental evidence for the efficacy of combined therapy of CPT-11 and hyperthermia for squamous cell carcinoma of the esophagus",

abstract = "Background/Aims: The aim of the current study was to show an anti-tumor effect for esophageal squamous carcinoma cells derived from a combination of hyperthermia and CPT-11, which would ultimately lead to the clinical usage of this therapeutic modality for patients with squamous cell carcinoma of the esophagus. Methodology: Survival fraction of esophageal squamous carcinoma cells after administrating SN-38, active metabolite of CPT-11, and combination of hyperthermia and SN-38 was compared using data measured by MTT assay. Results: Reduction of cell survival fraction derived by simultaneous induction of hyperthermia and SN-38, in many combinations of the temperature and charging period, was significantly greater than that acquired by SN-38 alone. Conclusions: Combination of hyperthermia and CPT-11 can exert a synergic anti-tumor efficacy for SCC of the esophagus.",

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TY - JOUR

T1 - Experimental evidence for the efficacy of combined therapy of CPT-11 and hyperthermia for squamous cell carcinoma of the esophagus

AU - Nozoe, Tadahiro

AU - Yasuda, Mitsuhiro

AU - Honda, Masayuki

AU - Imutsuka, Sadaaki

AU - Korenaga, Daisuke

PY - 2007/12/1

Y1 - 2007/12/1

N2 - Background/Aims: The aim of the current study was to show an anti-tumor effect for esophageal squamous carcinoma cells derived from a combination of hyperthermia and CPT-11, which would ultimately lead to the clinical usage of this therapeutic modality for patients with squamous cell carcinoma of the esophagus. Methodology: Survival fraction of esophageal squamous carcinoma cells after administrating SN-38, active metabolite of CPT-11, and combination of hyperthermia and SN-38 was compared using data measured by MTT assay. Results: Reduction of cell survival fraction derived by simultaneous induction of hyperthermia and SN-38, in many combinations of the temperature and charging period, was significantly greater than that acquired by SN-38 alone. Conclusions: Combination of hyperthermia and CPT-11 can exert a synergic anti-tumor efficacy for SCC of the esophagus.

AB - Background/Aims: The aim of the current study was to show an anti-tumor effect for esophageal squamous carcinoma cells derived from a combination of hyperthermia and CPT-11, which would ultimately lead to the clinical usage of this therapeutic modality for patients with squamous cell carcinoma of the esophagus. Methodology: Survival fraction of esophageal squamous carcinoma cells after administrating SN-38, active metabolite of CPT-11, and combination of hyperthermia and SN-38 was compared using data measured by MTT assay. Results: Reduction of cell survival fraction derived by simultaneous induction of hyperthermia and SN-38, in many combinations of the temperature and charging period, was significantly greater than that acquired by SN-38 alone. Conclusions: Combination of hyperthermia and CPT-11 can exert a synergic anti-tumor efficacy for SCC of the esophagus.

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IS - 80

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Experimental evidence for the efficacy of combined therapy of CPT-11 and hyperthermia for squamous cell carcinoma of the esophagus

Abstract

All Science Journal Classification (ASJC) codes

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