Expansion of NKG2C-expressing natural killer cells after umbilical cord blood transplantation in a patient with peripheral T-cell lymphoma with cytotoxic molecules

Tsuyoshi Muta; Tomoyasu Yoshihiro; Fumiaki Jinnouchi; Kenichi Aoki; Yu Kochi; Takahiro Shima; Katsuto Takenaka; Ryosuke Ogawa; Koichi Akashi; Koichi Oshima

doi:10.2169/internalmedicine.9437-17

Expansion of NKG2C-expressing natural killer cells after umbilical cord blood transplantation in a patient with peripheral T-cell lymphoma with cytotoxic molecules

Tsuyoshi Muta, Tomoyasu Yoshihiro, Fumiaki Jinnouchi, Kenichi Aoki, Yu Kochi, Takahiro Shima, Katsuto Takenaka, Ryosuke Ogawa, Koichi Akashi, Koichi Oshima

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8 Citations (Scopus)

Abstract

A 64-year-old woman presented with generalized lymphadenopathy and systemic manifestations. The examination of a biopsy specimen revealed peripheral T-cell lymphoma not otherwise specified (PTCL-NOS) expressing cytotoxic molecules. Umbilical cord blood transplantation was successful during a partial remission state after the administration of salvage chemotherapy. The donor-derived large granular lymphocytes started to increase as a result of cytomegalovirus reactivation. The fraction of natural killer (NK) cells expressing the NKG2C molecule accounted for one-third of the total lymphocytes for almost two years. We implicitly indicate the association between the persistence of donor-derived NKG2C⁺ NK cell-expansion and maintaining a complete remission in similar cases of aggressive PTCL-NOS.

Original language	English
Pages (from-to)	861-866
Number of pages	6
Journal	Internal Medicine
Volume	57
Issue number	6
DOIs	https://doi.org/10.2169/internalmedicine.9437-17
Publication status	Published - 2018

All Science Journal Classification (ASJC) codes

Internal Medicine

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Muta, T., Yoshihiro, T., Jinnouchi, F., Aoki, K., Kochi, Y., Shima, T., Takenaka, K., Ogawa, R., Akashi, K., & Oshima, K. (2018). Expansion of NKG2C-expressing natural killer cells after umbilical cord blood transplantation in a patient with peripheral T-cell lymphoma with cytotoxic molecules. Internal Medicine, 57(6), 861-866. https://doi.org/10.2169/internalmedicine.9437-17

Muta, T, Yoshihiro, T, Jinnouchi, F, Aoki, K, Kochi, Y, Shima, T, Takenaka, K, Ogawa, R, Akashi, K & Oshima, K 2018, 'Expansion of NKG2C-expressing natural killer cells after umbilical cord blood transplantation in a patient with peripheral T-cell lymphoma with cytotoxic molecules', Internal Medicine, vol. 57, no. 6, pp. 861-866. https://doi.org/10.2169/internalmedicine.9437-17

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abstract = "A 64-year-old woman presented with generalized lymphadenopathy and systemic manifestations. The examination of a biopsy specimen revealed peripheral T-cell lymphoma not otherwise specified (PTCL-NOS) expressing cytotoxic molecules. Umbilical cord blood transplantation was successful during a partial remission state after the administration of salvage chemotherapy. The donor-derived large granular lymphocytes started to increase as a result of cytomegalovirus reactivation. The fraction of natural killer (NK) cells expressing the NKG2C molecule accounted for one-third of the total lymphocytes for almost two years. We implicitly indicate the association between the persistence of donor-derived NKG2C+ NK cell-expansion and maintaining a complete remission in similar cases of aggressive PTCL-NOS.",

author = "Tsuyoshi Muta and Tomoyasu Yoshihiro and Fumiaki Jinnouchi and Kenichi Aoki and Yu Kochi and Takahiro Shima and Katsuto Takenaka and Ryosuke Ogawa and Koichi Akashi and Koichi Oshima",

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AU - Muta, Tsuyoshi

AU - Yoshihiro, Tomoyasu

AU - Jinnouchi, Fumiaki

AU - Aoki, Kenichi

AU - Kochi, Yu

AU - Shima, Takahiro

AU - Takenaka, Katsuto

AU - Ogawa, Ryosuke

AU - Akashi, Koichi

AU - Oshima, Koichi

PY - 2018

Y1 - 2018

N2 - A 64-year-old woman presented with generalized lymphadenopathy and systemic manifestations. The examination of a biopsy specimen revealed peripheral T-cell lymphoma not otherwise specified (PTCL-NOS) expressing cytotoxic molecules. Umbilical cord blood transplantation was successful during a partial remission state after the administration of salvage chemotherapy. The donor-derived large granular lymphocytes started to increase as a result of cytomegalovirus reactivation. The fraction of natural killer (NK) cells expressing the NKG2C molecule accounted for one-third of the total lymphocytes for almost two years. We implicitly indicate the association between the persistence of donor-derived NKG2C+ NK cell-expansion and maintaining a complete remission in similar cases of aggressive PTCL-NOS.

AB - A 64-year-old woman presented with generalized lymphadenopathy and systemic manifestations. The examination of a biopsy specimen revealed peripheral T-cell lymphoma not otherwise specified (PTCL-NOS) expressing cytotoxic molecules. Umbilical cord blood transplantation was successful during a partial remission state after the administration of salvage chemotherapy. The donor-derived large granular lymphocytes started to increase as a result of cytomegalovirus reactivation. The fraction of natural killer (NK) cells expressing the NKG2C molecule accounted for one-third of the total lymphocytes for almost two years. We implicitly indicate the association between the persistence of donor-derived NKG2C+ NK cell-expansion and maintaining a complete remission in similar cases of aggressive PTCL-NOS.

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Expansion of NKG2C-expressing natural killer cells after umbilical cord blood transplantation in a patient with peripheral T-cell lymphoma with cytotoxic molecules

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