@article{02436ddffe5f4370acc3da3540b6cae7,
title = "Expanding the synthesizable multisubstituted benzo[b] thiophenes via 6,7-thienobenzynes generated from o -silylaryl triflate-type precursors",
abstract = "Various 2,3-disubstituted 6,7-thienobenzynes have been efficiently generated from the corresponding o-silylaryl triflate-type precursors by activation with fluoride ions. The method has expanded the scope of synthesizable multisubstituted benzothiophenes, including those with various heteroatom substituents, and can be applied to the synthesis of EP4 antagonist analogs.",
author = "Suguru Yoshida and Tomoko Kuribara and Takamoto Morita and Tsubasa Matsuzawa and Kazushi Morimoto and Takuya Kobayashi and Takamitsu Hosoya",
note = "Funding Information: This work was supported by AMED under Grant Numbers JP18am0101098 (Platform Project for Supporting Drug Discovery and Life Science Research (BINDS)) and JP18gm0910007 (CREST; T. Kobayashi and T. H); JSPS KAKENHI Grant Numbers 15H03118 and 18H02104 (B; T. H.), 16H01133 and 18H04386 (Middle Molecular Strategy; T. H.), and 26350971 (C; S. Y.); Suntory Foundation for Life Sciences (S. Y.); Naito Foundation (S. Y.); and the Cooperative Research Project of Research Center for Biomedical Engineering. Publisher Copyright: {\textcopyright} 2018 The Royal Society of Chemistry.",
year = "2018",
doi = "10.1039/c8ra04035d",
language = "English",
volume = "8",
pages = "21754--21758",
journal = "RSC Advances",
issn = "2046-2069",
publisher = "Royal Society of Chemistry",
number = "39",
}