Exosomes from oral squamous carcinoma cell lines, SQUU-A and SQUU-B, define the tropism of lymphatic dissemination

Masahiko Morioka; Tomoyo Kawakubo-Yasukochi; Yoshikazu Hayashi; Mai Hazekawa; Takuya Nishinakagawa; Kazuhiko Ono; Shintaro Kawano; Seiji Nakamura; Manabu Nakashima

doi:10.1016/j.job.2016.05.001

Exosomes from oral squamous carcinoma cell lines, SQUU-A and SQUU-B, define the tropism of lymphatic dissemination

Masahiko Morioka, Tomoyo Kawakubo-Yasukochi, Yoshikazu Hayashi, Mai Hazekawa, Takuya Nishinakagawa, Kazuhiko Ono, Shintaro Kawano, Seiji Nakamura, Manabu Nakashima

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

Oral squamous cell carcinoma (OSCC) is often associated with lymphatic rather than hematogenous metastasis; however, a determinant factor for this process has not been elucidated. This study examined the effect of OSCC-derived exosomes on angiogenesis and lymphangiogenesis, closely related with hematogenous and lymphatic metastasis, respectively. Our data demonstrated that OSCC-derived exosomes stimulated the expression of VEGFs and their receptors, essential regulators of angiogenesis and lymphangiogenesis, in human lymphatic endothelial cells but not in human vein endothelial cells. These results suggest that specific exosomes have differential tropism toward a certain cell type, defining the modality of metastasis.

Original language	English
Pages (from-to)	180-184
Number of pages	5
Journal	journal of oral biosciences
Volume	58
Issue number	4
DOIs	https://doi.org/10.1016/j.job.2016.05.001
Publication status	Published - Nov 1 2016

All Science Journal Classification (ASJC) codes

Medicine (miscellaneous)
Biochemistry, Genetics and Molecular Biology(all)
Dentistry(all)

Access to Document

10.1016/j.job.2016.05.001

Cite this

@article{578c51326fbd46cfa5a7f0a4db8263b9,

title = "Exosomes from oral squamous carcinoma cell lines, SQUU-A and SQUU-B, define the tropism of lymphatic dissemination",

abstract = "Oral squamous cell carcinoma (OSCC) is often associated with lymphatic rather than hematogenous metastasis; however, a determinant factor for this process has not been elucidated. This study examined the effect of OSCC-derived exosomes on angiogenesis and lymphangiogenesis, closely related with hematogenous and lymphatic metastasis, respectively. Our data demonstrated that OSCC-derived exosomes stimulated the expression of VEGFs and their receptors, essential regulators of angiogenesis and lymphangiogenesis, in human lymphatic endothelial cells but not in human vein endothelial cells. These results suggest that specific exosomes have differential tropism toward a certain cell type, defining the modality of metastasis.",

author = "Masahiko Morioka and Tomoyo Kawakubo-Yasukochi and Yoshikazu Hayashi and Mai Hazekawa and Takuya Nishinakagawa and Kazuhiko Ono and Shintaro Kawano and Seiji Nakamura and Manabu Nakashima",

note = "Publisher Copyright: {\textcopyright} 2016 Japanese Association for Oral Biology",

year = "2016",

month = nov,

day = "1",

doi = "10.1016/j.job.2016.05.001",

language = "English",

volume = "58",

pages = "180--184",

journal = "journal of oral biosciences",

issn = "1349-0079",

publisher = "Japanese Association for Oral Biology",

number = "4",

}

TY - JOUR

T1 - Exosomes from oral squamous carcinoma cell lines, SQUU-A and SQUU-B, define the tropism of lymphatic dissemination

AU - Morioka, Masahiko

AU - Kawakubo-Yasukochi, Tomoyo

AU - Hayashi, Yoshikazu

AU - Hazekawa, Mai

AU - Nishinakagawa, Takuya

AU - Ono, Kazuhiko

AU - Kawano, Shintaro

AU - Nakamura, Seiji

AU - Nakashima, Manabu

PY - 2016/11/1

Y1 - 2016/11/1

N2 - Oral squamous cell carcinoma (OSCC) is often associated with lymphatic rather than hematogenous metastasis; however, a determinant factor for this process has not been elucidated. This study examined the effect of OSCC-derived exosomes on angiogenesis and lymphangiogenesis, closely related with hematogenous and lymphatic metastasis, respectively. Our data demonstrated that OSCC-derived exosomes stimulated the expression of VEGFs and their receptors, essential regulators of angiogenesis and lymphangiogenesis, in human lymphatic endothelial cells but not in human vein endothelial cells. These results suggest that specific exosomes have differential tropism toward a certain cell type, defining the modality of metastasis.

AB - Oral squamous cell carcinoma (OSCC) is often associated with lymphatic rather than hematogenous metastasis; however, a determinant factor for this process has not been elucidated. This study examined the effect of OSCC-derived exosomes on angiogenesis and lymphangiogenesis, closely related with hematogenous and lymphatic metastasis, respectively. Our data demonstrated that OSCC-derived exosomes stimulated the expression of VEGFs and their receptors, essential regulators of angiogenesis and lymphangiogenesis, in human lymphatic endothelial cells but not in human vein endothelial cells. These results suggest that specific exosomes have differential tropism toward a certain cell type, defining the modality of metastasis.

UR - http://www.scopus.com/inward/record.url?scp=84971671399&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84971671399&partnerID=8YFLogxK

U2 - 10.1016/j.job.2016.05.001

DO - 10.1016/j.job.2016.05.001

M3 - Article

AN - SCOPUS:84971671399

SN - 1349-0079

VL - 58

SP - 180

EP - 184

JO - journal of oral biosciences

JF - journal of oral biosciences

IS - 4

ER -

Exosomes from oral squamous carcinoma cell lines, SQUU-A and SQUU-B, define the tropism of lymphatic dissemination

Abstract

All Science Journal Classification (ASJC) codes

Access to Document

Other files and links

Fingerprint

Cite this