Exercise training causes sympathoinhibition through antioxidant effect in the rostral ventrolateral medulla of hypertensive rats

Takuya Kishi; Yoshitaka Hirooka; Masato Katsuki; Kiyohiro Ogawa; Keisuke Shinohara; Kengo Isegawa; Kenji Sunagawa

doi:10.3109/10641963.2012.681084

Exercise training causes sympathoinhibition through antioxidant effect in the rostral ventrolateral medulla of hypertensive rats

Takuya Kishi, Yoshitaka Hirooka, Masato Katsuki, Kiyohiro Ogawa, Keisuke Shinohara, Kengo Isegawa, Kenji Sunagawa

Research output: Contribution to journal › Article › peer-review

25 Citations (Scopus)

Abstract

Exercise training normalizes sympathetic outflow in hypertension and chronic heart failure. The aim of this study was to determine whether the exercise training inhibits sympathetic nerve activity (SNA) via reduction of oxidative stress through blocked angiotensin II type 1 receptor (AT1R) in rostral ventrolateral medulla (RVLM). We divided stroke-prone spontaneously hypertensive rats (SHRSP) into SHRSP with exercised training (SHRSP-EX) and control (SHRSP-C). SNA and oxidative stress in the RVLM were significantly lower in SHRSP-EX than in SHRSP-C. These results suggest that exercise training inhibits SNA via reduction of oxidative stress through blocked AT1R in the RVLM of hypertension.

Original language	English
Pages (from-to)	278-283
Number of pages	6
Journal	Clinical and Experimental Hypertension
Volume	34
Issue number	4
DOIs	https://doi.org/10.3109/10641963.2012.681084
Publication status	Published - Jul 2012
Externally published	Yes

All Science Journal Classification (ASJC) codes

Internal Medicine
Physiology

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10.3109/10641963.2012.681084

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title = "Exercise training causes sympathoinhibition through antioxidant effect in the rostral ventrolateral medulla of hypertensive rats",

abstract = "Exercise training normalizes sympathetic outflow in hypertension and chronic heart failure. The aim of this study was to determine whether the exercise training inhibits sympathetic nerve activity (SNA) via reduction of oxidative stress through blocked angiotensin II type 1 receptor (AT1R) in rostral ventrolateral medulla (RVLM). We divided stroke-prone spontaneously hypertensive rats (SHRSP) into SHRSP with exercised training (SHRSP-EX) and control (SHRSP-C). SNA and oxidative stress in the RVLM were significantly lower in SHRSP-EX than in SHRSP-C. These results suggest that exercise training inhibits SNA via reduction of oxidative stress through blocked AT1R in the RVLM of hypertension.",

author = "Takuya Kishi and Yoshitaka Hirooka and Masato Katsuki and Kiyohiro Ogawa and Keisuke Shinohara and Kengo Isegawa and Kenji Sunagawa",

note = "Funding Information: This study was supported by a Grant-in-Aid for Scientific Research from the Japan Society for the Promotion of Science (B19390231) and, in part, by the Health and Labor Sciences Research Grant for Comprehensive Research in Aging and Health Labor and Welfare of Japan. I thank my family, Satomi and Jiro.",

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AU - Kishi, Takuya

AU - Hirooka, Yoshitaka

AU - Katsuki, Masato

AU - Ogawa, Kiyohiro

AU - Shinohara, Keisuke

AU - Isegawa, Kengo

AU - Sunagawa, Kenji

N1 - Funding Information: This study was supported by a Grant-in-Aid for Scientific Research from the Japan Society for the Promotion of Science (B19390231) and, in part, by the Health and Labor Sciences Research Grant for Comprehensive Research in Aging and Health Labor and Welfare of Japan. I thank my family, Satomi and Jiro.

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AB - Exercise training normalizes sympathetic outflow in hypertension and chronic heart failure. The aim of this study was to determine whether the exercise training inhibits sympathetic nerve activity (SNA) via reduction of oxidative stress through blocked angiotensin II type 1 receptor (AT1R) in rostral ventrolateral medulla (RVLM). We divided stroke-prone spontaneously hypertensive rats (SHRSP) into SHRSP with exercised training (SHRSP-EX) and control (SHRSP-C). SNA and oxidative stress in the RVLM were significantly lower in SHRSP-EX than in SHRSP-C. These results suggest that exercise training inhibits SNA via reduction of oxidative stress through blocked AT1R in the RVLM of hypertension.

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Exercise training causes sympathoinhibition through antioxidant effect in the rostral ventrolateral medulla of hypertensive rats

Abstract

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