TY - JOUR
T1 - Excellent acceleration of the Diels-Alder reaction by microwave irradiation for the synthesis of new fluorine-substituted ligands of NMDA receptor
AU - Sasaki, Shigeki
AU - Ishibashi, Nobuyasu
AU - Kuwamura, Tshuneo
AU - Sano, Hiromi
AU - Matoba, Masaki
AU - Nisikawa, Tohru
AU - Maeda, Minora
N1 - Funding Information:
This study was partially supported by CREST (Core Research for Evolutional Science and Technology) of Japan Science and Technology Corporation (JST). We are also grateful for support by Grant-in-Aid for Scientific Research (B) from the Ministry of Education, Science, Sports and Culture, Japan.
PY - 1998/11
Y1 - 1998/11
N2 - A series of 6,11-ethanobenzo[b]quinolizinium derivatives was synthesized through the Diels-Alder reaction between azoniaanthracne and the corresponding 1,1-disubstituted olefin. After a systematic investigation for achieving rapid synthesis, it was found that the reaction is accelerated in polar media such as H2O and trifluoroethanol. In particular, excellent acceleration was effected by microwave irradiation. The new fluorine- substituted ligands thus obtained exhibited potential affinity toward NMDA receptors.
AB - A series of 6,11-ethanobenzo[b]quinolizinium derivatives was synthesized through the Diels-Alder reaction between azoniaanthracne and the corresponding 1,1-disubstituted olefin. After a systematic investigation for achieving rapid synthesis, it was found that the reaction is accelerated in polar media such as H2O and trifluoroethanol. In particular, excellent acceleration was effected by microwave irradiation. The new fluorine- substituted ligands thus obtained exhibited potential affinity toward NMDA receptors.
UR - http://www.scopus.com/inward/record.url?scp=0032211603&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0032211603&partnerID=8YFLogxK
U2 - 10.1016/S0960-894X(98)00541-1
DO - 10.1016/S0960-894X(98)00541-1
M3 - Article
C2 - 9873659
AN - SCOPUS:0032211603
SN - 0960-894X
VL - 8
SP - 2983
EP - 2986
JO - Bioorganic and Medicinal Chemistry Letters
JF - Bioorganic and Medicinal Chemistry Letters
IS - 21
ER -