Evolutionary design of oscillatory genetic networks in silico

Yuki Naruse; Hiroyuki Hamada; Taizo Hanai; Hitoshi Iba

doi:10.1109/CEC.2015.7257078

Evolutionary design of oscillatory genetic networks in silico

Yuki Naruse, Hiroyuki Hamada, Taizo Hanai, Hitoshi Iba

Systems Biology

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

1 Citation (Scopus)

Abstract

The design of genetic networks has been studied for implementing desired biological systems, and in particular, some researchers have proposed automatic design methods using optimization techniques. However, it is difficult to implement genetic networks designed by previous methods due to overly simplified model descriptions whose parameters are infeasible in the real world. Additionally, the methods do not ensure robustness against parameter perturbation. In this paper, we propose a two-stage design method and a fitness function evaluating robustness to create genetic networks which can be implemented experimentally. Further, we suggest the knowledge about robust network structures from results of optimization.

Original language	English
Title of host publication	2015 IEEE Congress on Evolutionary Computation, CEC 2015 - Proceedings
Publisher	Institute of Electrical and Electronics Engineers Inc.
Pages	1596-1603
Number of pages	8
ISBN (Electronic)	9781479974924
DOIs	https://doi.org/10.1109/CEC.2015.7257078
Publication status	Published - Sept 10 2015
Event	IEEE Congress on Evolutionary Computation, CEC 2015 - Sendai, Japan Duration: May 25 2015 → May 28 2015

Other

Other	IEEE Congress on Evolutionary Computation, CEC 2015
Country/Territory	Japan
City	Sendai
Period	5/25/15 → 5/28/15

All Science Journal Classification (ASJC) codes

Computer Science Applications
Computational Mathematics

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10.1109/CEC.2015.7257078

Cite this

Naruse, Y, Hamada, H , Hanai, T & Iba, H 2015, Evolutionary design of oscillatory genetic networks in silico. in 2015 IEEE Congress on Evolutionary Computation, CEC 2015 - Proceedings., 7257078, Institute of Electrical and Electronics Engineers Inc., pp. 1596-1603, IEEE Congress on Evolutionary Computation, CEC 2015, Sendai, Japan, 5/25/15. https://doi.org/10.1109/CEC.2015.7257078

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Evolutionary design of oscillatory genetic networks in silico

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