TY - JOUR
T1 - Evaluation of trabecular bone formation in a canine model surrounding a dental implant fixture immobilized with an antimicrobial peptide derived from histatin
AU - Makihira, Seicho
AU - Nikawa, Hiroki
AU - Shuto, Takahiro
AU - Nishimura, Masahiro
AU - Mine, Yuichi
AU - Tsuji, Koichiro
AU - Okamoto, Keishi
AU - Sakai, Yuhiro
AU - Sakai, Masanori
AU - Imari, Naoya
AU - Iwata, Satoshi
AU - Takeda, Mika
AU - Suehiro, Fumio
N1 - Funding Information:
Acknowledgments This study was performed with the cooperation of the Regional Innovation Creation Research and Development Business Program of the Japan Ministry of Economy, Trade and Industry in Japan (2008–2009). The authors thank Mr. K. Mamada, Mr. L. Takanohashi, Mr. H. Yoshihara (GC Corporation), and Mr. S. Okazaki (Hiroshima University) for their kind technical support in surgery and in the microCT examinations.
PY - 2011/12
Y1 - 2011/12
N2 - JH8194 induces osteoblast differentiation, although it was originally designed to improve antifungal activity. This suggests that JH8194 is useful for implant treatment. Therefore, the aim of this study was to evaluate the osseointegration capacity of JH8194-modified titanium dental implant fixtures (JH8194-Fi). The implants were randomly implanted into the edentulous ridge of dog mandibles. Healing abutments were inserted immediately after implant placement. Three weeks later, peri-implant bone levels, the first bone-to-implant contact points, and trabecular bone formation surrounding the implants were assessed by histological and digital image analyses based on microcomputed tomography (microCT). The histological analysis revealed an enhancement of mature trabecular bone around the JH8194-Fi compared with untreated fixtures (control-Fi). Similarly, microCT combined with analysis by Zed View ™ also showed increased trabecular bone formation surrounding the JH8194-Fi compared with the control-Fi (Student's t-test, P < 0.05). JH8194 may offer an alternative biological modification of titanium surfaces to enhance trabecular bone formation around dental implants, which may contribute to the transient acquirement of osseointegration and the long-term success of implant therapy.
AB - JH8194 induces osteoblast differentiation, although it was originally designed to improve antifungal activity. This suggests that JH8194 is useful for implant treatment. Therefore, the aim of this study was to evaluate the osseointegration capacity of JH8194-modified titanium dental implant fixtures (JH8194-Fi). The implants were randomly implanted into the edentulous ridge of dog mandibles. Healing abutments were inserted immediately after implant placement. Three weeks later, peri-implant bone levels, the first bone-to-implant contact points, and trabecular bone formation surrounding the implants were assessed by histological and digital image analyses based on microcomputed tomography (microCT). The histological analysis revealed an enhancement of mature trabecular bone around the JH8194-Fi compared with untreated fixtures (control-Fi). Similarly, microCT combined with analysis by Zed View ™ also showed increased trabecular bone formation surrounding the JH8194-Fi compared with the control-Fi (Student's t-test, P < 0.05). JH8194 may offer an alternative biological modification of titanium surfaces to enhance trabecular bone formation around dental implants, which may contribute to the transient acquirement of osseointegration and the long-term success of implant therapy.
UR - http://www.scopus.com/inward/record.url?scp=84355161727&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84355161727&partnerID=8YFLogxK
U2 - 10.1007/s10856-011-4440-2
DO - 10.1007/s10856-011-4440-2
M3 - Article
C2 - 21901371
AN - SCOPUS:84355161727
SN - 0957-4530
VL - 22
SP - 2765
EP - 2772
JO - Journal of Materials Science: Materials in Medicine
JF - Journal of Materials Science: Materials in Medicine
IS - 12
ER -