It was found from in vitro experiments that optimum superficial velocity in multi-capillary (MC) PUF packed-bed was about 65.1 cm/min , which improved the performance of the artificial liver without reducing the immobilizing ratio of hepatocyte/spheroid in MC-PUF packed-bed. By the optimization of medium (or plasma) flow rate and scaling up of MC- PUF/spheroid packed-bed, it was achieved that the decrease of ammonia concentration and repression of increase of bilirubin concentration and of artificial liver module side circulation line in extracorporeal circulation with severe hepatic failure rats.
|Number of pages||5|
|Journal||Japanese Journal of Artificial Organs|
|Publication status||Published - 1996|
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