TY - JOUR
T1 - Evaluation of echogenicity of the heart in Kawasaki disease
AU - Nagata, Hazumu
AU - Yamamura, Kenichiro
AU - Uike, Kiyoshi
AU - Nakashima, Yasutaka
AU - Hirata, Yuichiro
AU - Morihana, Eiji
AU - Mizuno, Yumi
AU - Ishikawa, Shiro
AU - Hara, Toshiro
PY - 2014/8
Y1 - 2014/8
N2 - Pathologic studies of the heart in patients with Kawasaki disease (KD) revealed vasculitis, valvulitis, myocarditis, and pericarditis. However, there have been no studies on the quantitative determination of multi-site echogenicity of the heart in KD patients. It is also undetermined whether the degree of echogenicity of each site of the heart in patients with KD might be related to the response to intravenous immunoglobulin (IVIG) treatment. In 81 KD patients and 30 control subjects, we prospectively analyzed echogenicity of the heart. Echogenicity was measured in four sites: coronary artery wall (CAW), mitral valve (MV), papillary muscle (PM), and ascending aortic wall (AAo wall) by the calibrated integrated backscatters (cIBs). The cIB values of all measurement sites at acute phase in KD patients were significantly higher than those in control subjects (KD patients vs control subjects; CAW, 19.8±6.2 dB vs 14.5±2.0 dB, p<0.05; MV, 23.3±5.3 dB vs 16.0±3.3 dB, p<0.05; PM, 22.4±5.1 dB vs 12.7±1.9 dB, p<0.05; AAo wall, 25.3±5.6 dB vs 18.3±3.4 dB, p<0.05). The cIB values of CAW at the acute phase in IVIG nonresponders were significantly higher than those in responders. Conclusion: Echogenicity of the heart in KD patients at the acute phase increased not only in the coronary artery wall but also in other parts of the heart. Echogenicity of CAW might be helpful in determining the unresponsiveness of IVIG treatment.
AB - Pathologic studies of the heart in patients with Kawasaki disease (KD) revealed vasculitis, valvulitis, myocarditis, and pericarditis. However, there have been no studies on the quantitative determination of multi-site echogenicity of the heart in KD patients. It is also undetermined whether the degree of echogenicity of each site of the heart in patients with KD might be related to the response to intravenous immunoglobulin (IVIG) treatment. In 81 KD patients and 30 control subjects, we prospectively analyzed echogenicity of the heart. Echogenicity was measured in four sites: coronary artery wall (CAW), mitral valve (MV), papillary muscle (PM), and ascending aortic wall (AAo wall) by the calibrated integrated backscatters (cIBs). The cIB values of all measurement sites at acute phase in KD patients were significantly higher than those in control subjects (KD patients vs control subjects; CAW, 19.8±6.2 dB vs 14.5±2.0 dB, p<0.05; MV, 23.3±5.3 dB vs 16.0±3.3 dB, p<0.05; PM, 22.4±5.1 dB vs 12.7±1.9 dB, p<0.05; AAo wall, 25.3±5.6 dB vs 18.3±3.4 dB, p<0.05). The cIB values of CAW at the acute phase in IVIG nonresponders were significantly higher than those in responders. Conclusion: Echogenicity of the heart in KD patients at the acute phase increased not only in the coronary artery wall but also in other parts of the heart. Echogenicity of CAW might be helpful in determining the unresponsiveness of IVIG treatment.
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U2 - 10.1007/s00431-014-2296-4
DO - 10.1007/s00431-014-2296-4
M3 - Article
C2 - 24659312
AN - SCOPUS:84904413470
SN - 0340-6199
VL - 173
SP - 1089
EP - 1093
JO - European Journal of Pediatrics
JF - European Journal of Pediatrics
IS - 8
ER -