TY - JOUR
T1 - Evaluation of biological activities of extracts from 22 African tropical wood species
AU - Huang, Zeen
AU - Hashida, Koh
AU - Makino, Rei
AU - Kawamura, Fumio
AU - Shimizu, Kuniyoshi
AU - Kondo, Ryuichiro
AU - Ohara, Seiji
N1 - Funding Information:
Acknowledgments This work was supported by a Grant-in-Aid for Scientific Research from the Japan Society for the Promotion of Science. The authors thank Mr. Alhassan Attah (Forestry Commission of Ghana), and Dr. P.R. Gillah (Department of Wood Utilization, Sokoine University of Agriculture, Morogoro, Tanzania) for kindly providing the wood samples for this study.
PY - 2009/6
Y1 - 2009/6
N2 - Heartwoods of 22 African tropical wood species were extracted with methanol and the contents of total phenolic compounds in these extracts were measured. Three bioassays were conducted to evaluate the antioxidant activity, tyrosinase inhibitory activity, and antifungal activity of the methanol extracts. The results indicated that the extracts from 13 species exhibited high antioxidant potential, and their inhibitory concentrations that caused 50% scavenging of the 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical (IC50) were less than 10 μg/ml. The crude extract from Cylicodiscus gabunensis showed the highest antioxidant activity, and was even higher than that of (+)-catechin, which is known as a potent antioxidant. There was a good correlation between the antioxidant activity and the content of total phenolic compounds, indicating that phenolic compounds played a predominant role in the antioxidant property of the wood extracts. Among all 22 species, only 1 species, Milicia excelsa, contained extractives that showed very high tyrosinase inhibitory activity. The extracts from 9 species showed high antifungal activity. No consistent relationship was observed between the tyrosinase inhibitory activity or antifungal activity and the content of total phenolics in the extracts.
AB - Heartwoods of 22 African tropical wood species were extracted with methanol and the contents of total phenolic compounds in these extracts were measured. Three bioassays were conducted to evaluate the antioxidant activity, tyrosinase inhibitory activity, and antifungal activity of the methanol extracts. The results indicated that the extracts from 13 species exhibited high antioxidant potential, and their inhibitory concentrations that caused 50% scavenging of the 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical (IC50) were less than 10 μg/ml. The crude extract from Cylicodiscus gabunensis showed the highest antioxidant activity, and was even higher than that of (+)-catechin, which is known as a potent antioxidant. There was a good correlation between the antioxidant activity and the content of total phenolic compounds, indicating that phenolic compounds played a predominant role in the antioxidant property of the wood extracts. Among all 22 species, only 1 species, Milicia excelsa, contained extractives that showed very high tyrosinase inhibitory activity. The extracts from 9 species showed high antifungal activity. No consistent relationship was observed between the tyrosinase inhibitory activity or antifungal activity and the content of total phenolics in the extracts.
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U2 - 10.1007/s10086-008-1024-y
DO - 10.1007/s10086-008-1024-y
M3 - Comment/debate
AN - SCOPUS:70349284766
SN - 1435-0211
VL - 55
SP - 225
EP - 229
JO - Journal of Wood Science
JF - Journal of Wood Science
IS - 3
ER -