Evaluation for cellular specificity of comb-type copolymer having hyaluronic acid side chains

Naohisa Fujii; Sung Won Choi; Arihiro Kano; Toshihiro Akaike; Atsushi Maruyama

Evaluation for cellular specificity of comb-type copolymer having hyaluronic acid side chains

Naohisa Fujii, Sung Won Choi, Arihiro Kano, Toshihiro Akaike, Atsushi Maruyama

Department of Fundamental Organic Chemistry

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

Nucleic acid medicines (e.g. RNAi, antisense etc.) have increasingly become a powerful tool for genetic analysis and are likely to become a potent therapeutic approach for intractable diseases. However, the major obstacle to use them as therapeutics is the difficulty of in vivo delivery. Though cationic comb-type polymer having HA side chains has used for site-specific delivery of plasmid DNA into liver sinusoidal endothelial cells (LSEC) effectively, it has less binding ability to short nucleic acid such as siRNAs and antisense DNA. Therefore we introduced guanidino moieties into PLL main chains to enhance the binding affinity.

Original language	English
Title of host publication	54th SPSJ Annual Meeting 2005 - Polymer Preprints, Japan
Pages	2147
Number of pages	1
Volume	54
Edition	1
Publication status	Published - 2005
Event	54th SPSJ Annual Meeting 2005 - Yokohama, Japan Duration: May 25 2005 → May 27 2005

Other

Other	54th SPSJ Annual Meeting 2005
Country/Territory	Japan
City	Yokohama
Period	5/25/05 → 5/27/05

All Science Journal Classification (ASJC) codes

Engineering(all)

Cite this

@inproceedings{32822feaf5534c4ab914d9e9208ec319,

title = "Evaluation for cellular specificity of comb-type copolymer having hyaluronic acid side chains",

abstract = "Nucleic acid medicines (e.g. RNAi, antisense etc.) have increasingly become a powerful tool for genetic analysis and are likely to become a potent therapeutic approach for intractable diseases. However, the major obstacle to use them as therapeutics is the difficulty of in vivo delivery. Though cationic comb-type polymer having HA side chains has used for site-specific delivery of plasmid DNA into liver sinusoidal endothelial cells (LSEC) effectively, it has less binding ability to short nucleic acid such as siRNAs and antisense DNA. Therefore we introduced guanidino moieties into PLL main chains to enhance the binding affinity.",

author = "Naohisa Fujii and Choi, {Sung Won} and Arihiro Kano and Toshihiro Akaike and Atsushi Maruyama",

year = "2005",

language = "English",

volume = "54",

pages = "2147",

booktitle = "54th SPSJ Annual Meeting 2005 - Polymer Preprints, Japan",

edition = "1",

note = "54th SPSJ Annual Meeting 2005 ; Conference date: 25-05-2005 Through 27-05-2005",

}

TY - GEN

T1 - Evaluation for cellular specificity of comb-type copolymer having hyaluronic acid side chains

AU - Fujii, Naohisa

AU - Choi, Sung Won

AU - Kano, Arihiro

AU - Akaike, Toshihiro

AU - Maruyama, Atsushi

PY - 2005

Y1 - 2005

N2 - Nucleic acid medicines (e.g. RNAi, antisense etc.) have increasingly become a powerful tool for genetic analysis and are likely to become a potent therapeutic approach for intractable diseases. However, the major obstacle to use them as therapeutics is the difficulty of in vivo delivery. Though cationic comb-type polymer having HA side chains has used for site-specific delivery of plasmid DNA into liver sinusoidal endothelial cells (LSEC) effectively, it has less binding ability to short nucleic acid such as siRNAs and antisense DNA. Therefore we introduced guanidino moieties into PLL main chains to enhance the binding affinity.

AB - Nucleic acid medicines (e.g. RNAi, antisense etc.) have increasingly become a powerful tool for genetic analysis and are likely to become a potent therapeutic approach for intractable diseases. However, the major obstacle to use them as therapeutics is the difficulty of in vivo delivery. Though cationic comb-type polymer having HA side chains has used for site-specific delivery of plasmid DNA into liver sinusoidal endothelial cells (LSEC) effectively, it has less binding ability to short nucleic acid such as siRNAs and antisense DNA. Therefore we introduced guanidino moieties into PLL main chains to enhance the binding affinity.

UR - http://www.scopus.com/inward/record.url?scp=33645641032&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33645641032&partnerID=8YFLogxK

M3 - Conference contribution

AN - SCOPUS:33645641032

VL - 54

SP - 2147

BT - 54th SPSJ Annual Meeting 2005 - Polymer Preprints, Japan

T2 - 54th SPSJ Annual Meeting 2005

Y2 - 25 May 2005 through 27 May 2005

ER -

Evaluation for cellular specificity of comb-type copolymer having hyaluronic acid side chains

Abstract

Other

All Science Journal Classification (ASJC) codes

Other files and links

Fingerprint

Cite this