Evaluating protein sequence signatures inferred from protein-protein interaction data by gene ontology annotations

Osamu Maruyama; Hideki Hirakawa; Takao Iwayanagi; Yoshiko Ishida; Shizu Takeda; Jun Otomo; Satoru Kuhara

doi:10.1109/BIBM.2008.29

Evaluating protein sequence signatures inferred from protein-protein interaction data by gene ontology annotations

Osamu Maruyama, Hideki Hirakawa, Takao Iwayanagi, Yoshiko Ishida, Shizu Takeda, Jun Otomo, Satoru Kuhara

Division of Applied Mathematics

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

We propose a systematic method to find sequence signatures of proteins which share a common interacting partner, using a protein similarity measure based on gene ontology (GO) annotations. In a computational experiment on our original human data set of protein-protein interactions determined by Y2H assays, we have succeeded in discovering convincing candidates for interacting sites and other functional regions.

Original language	English
Title of host publication	Proceedings - IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2008
Pages	417-420
Number of pages	4
DOIs	https://doi.org/10.1109/BIBM.2008.29
Publication status	Published - Dec 1 2008
Event	2008 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2008 - Philadelphia, PA, United States Duration: Nov 3 2008 → Nov 5 2008

Other

Other	2008 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2008
Country/Territory	United States
City	Philadelphia, PA
Period	11/3/08 → 11/5/08

All Science Journal Classification (ASJC) codes

Molecular Biology
Information Systems
Biomedical Engineering

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10.1109/BIBM.2008.29

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Maruyama, O., Hirakawa, H., Iwayanagi, T., Ishida, Y., Takeda, S., Otomo, J., & Kuhara, S. (2008). Evaluating protein sequence signatures inferred from protein-protein interaction data by gene ontology annotations. In Proceedings - IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2008 (pp. 417-420). Article 4684931 https://doi.org/10.1109/BIBM.2008.29

Evaluating protein sequence signatures inferred from protein-protein interaction data by gene ontology annotations. / Maruyama, Osamu; Hirakawa, Hideki; Iwayanagi, Takao et al.
Proceedings - IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2008. 2008. p. 417-420 4684931.

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Maruyama, O, Hirakawa, H, Iwayanagi, T, Ishida, Y, Takeda, S, Otomo, J & Kuhara, S 2008, Evaluating protein sequence signatures inferred from protein-protein interaction data by gene ontology annotations. in Proceedings - IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2008., 4684931, pp. 417-420, 2008 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2008, Philadelphia, PA, United States, 11/3/08. https://doi.org/10.1109/BIBM.2008.29

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AU - Otomo, Jun

AU - Kuhara, Satoru

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Evaluating protein sequence signatures inferred from protein-protein interaction data by gene ontology annotations

Abstract

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All Science Journal Classification (ASJC) codes

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