Etiology and molecular biology of hyperproinsulinemia

N. Nakashima, F. Umeda

Research output: Contribution to journalReview articlepeer-review

1 Citation (Scopus)


Clinical hyperproinsulinemia occurs not only in familial hyperproinsulinemia, but also in insulinoma, renal failure, and even in non-insulin-dependent diabetes mellitus (NIDDM). The etiology of hyperproinsulinemia is divided into (1) abnormality of pro-insulin molecules, (2) abnormality of pancreatic beta-cells other than proinsulin molecules, (3) retardation of proinsulin clearance. Hyperproinsulinemia is now thought to be both a result of the above-mentioned diseases and a cause of atherosclerosis in patients with NIDDM. Recent developments in molecular biology have deepened our knowledge of the biosynthesis and role of proinsulin, especially the prohormone sorting mechanism into secretory granules in pancreatic beta-cells.

Original languageEnglish
Pages (from-to)2556-2561
Number of pages6
JournalNippon rinsho. Japanese journal of clinical medicine
Issue number10
Publication statusPublished - Oct 1994

All Science Journal Classification (ASJC) codes

  • General Medicine


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